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Catechol-based zwitterionic polymers with antibacterial and antifouling properties for biomedical surface coatings.

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Title: Catechol-based zwitterionic polymers with antibacterial and antifouling properties for biomedical surface coatings.
Authors: Hou, Shan-Wei1 (AUTHOR), Chang, Jui-Jen2,3 (AUTHOR), Lin, Li-Ying1 (AUTHOR), Pham, Uyen Khanh1 (AUTHOR), Do, Thi Thu Ha1 (AUTHOR), Lee, Cheng-Kang1 (AUTHOR), Hsiao, Wesley Wei-Wen1 (AUTHOR) weshsiao@mail.ntust.edu.tw
Source: Progress in Organic Coatings. Apr2026, Vol. 213, pN.PAG-N.PAG. 1p.
Subjects: Antibacterial agents, Biofilms, Functional groups, Polyethylene glycol, Surface preparation, Biocides, Polyzwitterions
Abstract: Persistent biofilms on medical device surfaces account for up to 80 % of chronic clinical infections, posing a major challenge to infection control and patient safety. To overcome this limitation, a zwitterionic polymer–PEGDGE-TAU-CCDP (PTC), was synthesized using polyethylene glycol diglycidyl ether (PEGDGE), taurine (TAU), and 2-chloro-3′,4′-dihydroxyacetophenone (CCDP). The incorporation of catechol functionalities enabled the polymer with redox activity under aerobic and ion-rich environments, a property previously associated with antibacterial behavior in catechol-based systems. Ultraviolet–visible (UV–Vis), Fourier-transform infrared (FTIR), and proton nuclear magnetic resonance (1H NMR) spectroscopy confirmed the successful synthesis and catechol incorporation. Quantitative analysis revealed a CCDP grafting efficiency of approximately 29 %. Notably, the addition of ε-Polylysine (EPL) enhanced coating adhesion to various substrates without compromising the intrinsic antibacterial activity of the material. Bacterial growth curves, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) assays demonstrated that EPL/PTC had an MIC of 0.31 mg/mL and an MBC of 1.25 mg/mL. Furthermore, the EPL/PTC-coated silicone rubber exhibited approximately 85 % biofilm inhibition and 76 % antifouling efficiency. By combining antifouling and antibacterial properties within a single system, this strategy achieves multifunctional performance that is rarely observed in conventional surface treatments. These findings highlight EPL/PTC as a promising candidate for reducing surface fouling and infection risks, thereby supporting its potential application in developing safer biomedical device materials. [Display omitted] • Cross-contamination remains a major challenge in medical device sterilization. • A novel zwitterionic polymer, PEGDGE-TAU-CCDP (PTC), exhibits strong antioxidant, antibacterial, and antifouling properties. • Incorporating ε-Polylysine (EPL) yields a hybrid coating (EPL/PTC) that reduces cross-contamination and helps prevent infections. • The coating is hydrophilic, highly antibacterial, and inhibits biofilm formation by up to 90%. • Enhanced adhesion, reduced tensile stress, and decreased cracking make it promising for medical applications. [ABSTRACT FROM AUTHOR]
Copyright of Progress in Organic Coatings is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 191296837
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Catechol-based zwitterionic polymers with antibacterial and antifouling properties for biomedical surface coatings.
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  Data: <searchLink fieldCode="AR" term="%22Hou%2C+Shan-Wei%22">Hou, Shan-Wei</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chang%2C+Jui-Jen%22">Chang, Jui-Jen</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lin%2C+Li-Ying%22">Lin, Li-Ying</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pham%2C+Uyen+Khanh%22">Pham, Uyen Khanh</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Do%2C+Thi+Thu+Ha%22">Do, Thi Thu Ha</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Cheng-Kang%22">Lee, Cheng-Kang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hsiao%2C+Wesley+Wei-Wen%22">Hsiao, Wesley Wei-Wen</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> weshsiao@mail.ntust.edu.tw</i>
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  Data: <searchLink fieldCode="JN" term="%22Progress+in+Organic+Coatings%22">Progress in Organic Coatings</searchLink>. Apr2026, Vol. 213, pN.PAG-N.PAG. 1p.
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  Data: <searchLink fieldCode="DE" term="%22Antibacterial+agents%22">Antibacterial agents</searchLink><br /><searchLink fieldCode="DE" term="%22Biofilms%22">Biofilms</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+groups%22">Functional groups</searchLink><br /><searchLink fieldCode="DE" term="%22Polyethylene+glycol%22">Polyethylene glycol</searchLink><br /><searchLink fieldCode="DE" term="%22Surface+preparation%22">Surface preparation</searchLink><br /><searchLink fieldCode="DE" term="%22Biocides%22">Biocides</searchLink><br /><searchLink fieldCode="DE" term="%22Polyzwitterions%22">Polyzwitterions</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Persistent biofilms on medical device surfaces account for up to 80 % of chronic clinical infections, posing a major challenge to infection control and patient safety. To overcome this limitation, a zwitterionic polymer–PEGDGE-TAU-CCDP (PTC), was synthesized using polyethylene glycol diglycidyl ether (PEGDGE), taurine (TAU), and 2-chloro-3′,4′-dihydroxyacetophenone (CCDP). The incorporation of catechol functionalities enabled the polymer with redox activity under aerobic and ion-rich environments, a property previously associated with antibacterial behavior in catechol-based systems. Ultraviolet–visible (UV–Vis), Fourier-transform infrared (FTIR), and proton nuclear magnetic resonance (1H NMR) spectroscopy confirmed the successful synthesis and catechol incorporation. Quantitative analysis revealed a CCDP grafting efficiency of approximately 29 %. Notably, the addition of ε-Polylysine (EPL) enhanced coating adhesion to various substrates without compromising the intrinsic antibacterial activity of the material. Bacterial growth curves, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) assays demonstrated that EPL/PTC had an MIC of 0.31 mg/mL and an MBC of 1.25 mg/mL. Furthermore, the EPL/PTC-coated silicone rubber exhibited approximately 85 % biofilm inhibition and 76 % antifouling efficiency. By combining antifouling and antibacterial properties within a single system, this strategy achieves multifunctional performance that is rarely observed in conventional surface treatments. These findings highlight EPL/PTC as a promising candidate for reducing surface fouling and infection risks, thereby supporting its potential application in developing safer biomedical device materials. [Display omitted] • Cross-contamination remains a major challenge in medical device sterilization. • A novel zwitterionic polymer, PEGDGE-TAU-CCDP (PTC), exhibits strong antioxidant, antibacterial, and antifouling properties. • Incorporating ε-Polylysine (EPL) yields a hybrid coating (EPL/PTC) that reduces cross-contamination and helps prevent infections. • The coating is hydrophilic, highly antibacterial, and inhibits biofilm formation by up to 90%. • Enhanced adhesion, reduced tensile stress, and decreased cracking make it promising for medical applications. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Progress in Organic Coatings is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.porgcoat.2025.109915
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Antibacterial agents
        Type: general
      – SubjectFull: Biofilms
        Type: general
      – SubjectFull: Functional groups
        Type: general
      – SubjectFull: Polyethylene glycol
        Type: general
      – SubjectFull: Surface preparation
        Type: general
      – SubjectFull: Biocides
        Type: general
      – SubjectFull: Polyzwitterions
        Type: general
    Titles:
      – TitleFull: Catechol-based zwitterionic polymers with antibacterial and antifouling properties for biomedical surface coatings.
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            NameFull: Hou, Shan-Wei
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            NameFull: Chang, Jui-Jen
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            NameFull: Lin, Li-Ying
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            NameFull: Pham, Uyen Khanh
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            NameFull: Do, Thi Thu Ha
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            NameFull: Lee, Cheng-Kang
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            NameFull: Hsiao, Wesley Wei-Wen
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            – D: 01
              M: 04
              Text: Apr2026
              Type: published
              Y: 2026
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              Value: 213
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            – TitleFull: Progress in Organic Coatings
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