View in EDS

Highly resilient pure sericin 3D scaffolds for tissue engineering.

Saved in:
Bibliographic Details
Title: Highly resilient pure sericin 3D scaffolds for tissue engineering.
Authors: Battampara, Prajwal1 (AUTHOR), Rao, Anjana S.1 (AUTHOR), Ramesh, Kavya Thattiguppe1 (AUTHOR), Reddy, Roopa1 (AUTHOR), Aramwit, Pornanong2,3,4 (AUTHOR) aramwit@gmail.com, Reddy, Narendra1,5 (AUTHOR) nreddy3@outlook.com
Source: International Journal of Polymeric Materials & Polymeric Biomaterials. 2026, Vol. 75 Issue 6, p697-705. 9p.
Subjects: Sericin, Tissue engineering, Cell survival, Vitamin C, Biocompatibility, Regenerative medicine, Interfacial bonding, Biomaterials
Abstract: Sericin, a water soluble and biocompatible silk protein, has gained significant interest for medical applications, yet obtaining stable pure sericin scaffolds in 3D form has remained challenging. In this study, pure sericin 3D scaffolds suitable for tissue engineering were developed by crosslinking with ascorbic acid. The scaffolds exhibited a compressive strength of 190 ± 2.1 kPa with complete recovery from deformation within 10 s, a tensile strength of 159 ± 14.1 kPa, a swelling index of 434.7 ± 6.1%, moisture content of 8.5%, and porosity of 18.3 ± 0.7%. SEM analysis revealed a porous network favorable for cell attachment and proliferation. The biocompatibility and bioactivity of the scaffolds were assessed through antioxidant assays and cell viability tests using NIH 3T3 fibroblast cells. The scaffolds displayed notable antioxidant activity (IC50 = 4.3 μg/mL), significantly lower than ascorbic acid standard. The scaffolds supported the growth and attachment of NIH3T3 cells, high cell viability and cells were able to penetrate into the scaffolds, asserting their potential for tissue engineering and regenerative medicine. Overall, our findings demonstrate that ascorbic acid cross-linked pure sericin 3D scaffolds possess the necessary properties for use in tissue engineering, offering a promising platform for further development of sericin for regenerative medicine. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Polymeric Materials & Polymeric Biomaterials is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 191332541
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Highly resilient pure sericin 3D scaffolds for tissue engineering.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Battampara%2C+Prajwal%22">Battampara, Prajwal</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rao%2C+Anjana+S%2E%22">Rao, Anjana S.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ramesh%2C+Kavya+Thattiguppe%22">Ramesh, Kavya Thattiguppe</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Reddy%2C+Roopa%22">Reddy, Roopa</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aramwit%2C+Pornanong%22">Aramwit, Pornanong</searchLink><relatesTo>2,3,4</relatesTo> (AUTHOR)<i> aramwit@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Reddy%2C+Narendra%22">Reddy, Narendra</searchLink><relatesTo>1,5</relatesTo> (AUTHOR)<i> nreddy3@outlook.com</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Polymeric+Materials+%26+Polymeric+Biomaterials%22">International Journal of Polymeric Materials & Polymeric Biomaterials</searchLink>. 2026, Vol. 75 Issue 6, p697-705. 9p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Sericin%22">Sericin</searchLink><br /><searchLink fieldCode="DE" term="%22Tissue+engineering%22">Tissue engineering</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+survival%22">Cell survival</searchLink><br /><searchLink fieldCode="DE" term="%22Vitamin+C%22">Vitamin C</searchLink><br /><searchLink fieldCode="DE" term="%22Biocompatibility%22">Biocompatibility</searchLink><br /><searchLink fieldCode="DE" term="%22Regenerative+medicine%22">Regenerative medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Interfacial+bonding%22">Interfacial bonding</searchLink><br /><searchLink fieldCode="DE" term="%22Biomaterials%22">Biomaterials</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Sericin, a water soluble and biocompatible silk protein, has gained significant interest for medical applications, yet obtaining stable pure sericin scaffolds in 3D form has remained challenging. In this study, pure sericin 3D scaffolds suitable for tissue engineering were developed by crosslinking with ascorbic acid. The scaffolds exhibited a compressive strength of 190 ± 2.1 kPa with complete recovery from deformation within 10 s, a tensile strength of 159 ± 14.1 kPa, a swelling index of 434.7 ± 6.1%, moisture content of 8.5%, and porosity of 18.3 ± 0.7%. SEM analysis revealed a porous network favorable for cell attachment and proliferation. The biocompatibility and bioactivity of the scaffolds were assessed through antioxidant assays and cell viability tests using NIH 3T3 fibroblast cells. The scaffolds displayed notable antioxidant activity (IC50 = 4.3 μg/mL), significantly lower than ascorbic acid standard. The scaffolds supported the growth and attachment of NIH3T3 cells, high cell viability and cells were able to penetrate into the scaffolds, asserting their potential for tissue engineering and regenerative medicine. Overall, our findings demonstrate that ascorbic acid cross-linked pure sericin 3D scaffolds possess the necessary properties for use in tissue engineering, offering a promising platform for further development of sericin for regenerative medicine. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Polymeric Materials & Polymeric Biomaterials is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=191332541
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/00914037.2025.2605165
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 697
    Subjects:
      – SubjectFull: Sericin
        Type: general
      – SubjectFull: Tissue engineering
        Type: general
      – SubjectFull: Cell survival
        Type: general
      – SubjectFull: Vitamin C
        Type: general
      – SubjectFull: Biocompatibility
        Type: general
      – SubjectFull: Regenerative medicine
        Type: general
      – SubjectFull: Interfacial bonding
        Type: general
      – SubjectFull: Biomaterials
        Type: general
    Titles:
      – TitleFull: Highly resilient pure sericin 3D scaffolds for tissue engineering.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Battampara, Prajwal
      – PersonEntity:
          Name:
            NameFull: Rao, Anjana S.
      – PersonEntity:
          Name:
            NameFull: Ramesh, Kavya Thattiguppe
      – PersonEntity:
          Name:
            NameFull: Reddy, Roopa
      – PersonEntity:
          Name:
            NameFull: Aramwit, Pornanong
      – PersonEntity:
          Name:
            NameFull: Reddy, Narendra
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: 2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 00914037
          Numbering:
            – Type: volume
              Value: 75
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: International Journal of Polymeric Materials & Polymeric Biomaterials
              Type: main
ResultId 1