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Synthesis, characterization and crystal structures of N′-(2-hydroxy-4-methoxybenzylidene)-3-methylbenzohydrazide and it's copper(II), cobalt(III) and zinc(II) complexes with antibacterial activity.

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Title:	Synthesis, characterization and crystal structures of N′-(2-hydroxy-4-methoxybenzylidene)-3-methylbenzohydrazide and it's copper(II), cobalt(III) and zinc(II) complexes with antibacterial activity.
Authors:	Mao, Fu-Lin¹ (AUTHOR) xpzhougroup@163.com
Source:	Inorganica Chimica Acta. May2026, Vol. 594, pN.PAG-N.PAG. 1p.
Subjects:	Crystal structure, Metal complexes, Antibacterial agents, Hydrazone derivatives, Zinc, Materials testing, Copper, Chemical synthesis
Abstract:	An aroylhydrazone compound N′ -(2-hydroxy-4-methoxybenzylidene)-3-methylbenzohydrazide (H 2 L) was prepared and characterized by IR, UV–Vis, 1H and 13C NMR spectra. Reaction of H 2 L with copper nitrate, cobalt nitrate and zinc iodide, respectively, afforded three new complexes [Cu 2 (HL) 2 (ONO 2) 2 ]∙2H 2 O (1 ∙2H 2 O), [Co 2 L 2 (EtOH) 2 (OH 2) 2 ]2NO 3 (2), and [Zn 2 I 2 (HL) 2 ]∙2EtOH (3 ∙2EtOH). The complexes have been characterized by IR and UV–Vis spectra. Structures of H 2 L and the complexes were further confirmed by single crystal X-ray determination. H 2 L crystallizes in monoclinic system space group P 2 1 / c , and the three complexes in triclinic P -1. Single crystal X-ray diffraction analysis reveals that the Cu atoms in 1 and Zn atoms in 3 are in square pyramidal coordination, and the Co atoms in 2 are in octahedral coordination. The compounds were assayed against the bacterial strains Bacillus subtillis , Staphylococcus aureus , Escherichia coli , and Pseudomonas aereuguinosa. The Cu and Zn complexes have effective antibacterial activities. [Display omitted] • The aroylhydrazone compound N′ -(2-hydroxy-4-methoxybenzylidene)-3-methylbenzohydrazide was newly synthesized. • The three complexes were newly synthesized. • Single crystal structures of the aroylhydrazone compound and the complexes were first reported. • The complexes have potential antibacterial activities on the bacterial strains Bacillus subtillis , Staphylococcus aureus , Escherichia coli , and Pseudomonas aereuguinosa. [ABSTRACT FROM AUTHOR]
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Database:	Engineering Source

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Abstract:	An aroylhydrazone compound N′ -(2-hydroxy-4-methoxybenzylidene)-3-methylbenzohydrazide (H 2 L) was prepared and characterized by IR, UV–Vis, 1H and 13C NMR spectra. Reaction of H 2 L with copper nitrate, cobalt nitrate and zinc iodide, respectively, afforded three new complexes [Cu 2 (HL) 2 (ONO 2) 2 ]∙2H 2 O (1 ∙2H 2 O), [Co 2 L 2 (EtOH) 2 (OH 2) 2 ]2NO 3 (2), and [Zn 2 I 2 (HL) 2 ]∙2EtOH (3 ∙2EtOH). The complexes have been characterized by IR and UV–Vis spectra. Structures of H 2 L and the complexes were further confirmed by single crystal X-ray determination. H 2 L crystallizes in monoclinic system space group P 2 1 / c , and the three complexes in triclinic P -1. Single crystal X-ray diffraction analysis reveals that the Cu atoms in 1 and Zn atoms in 3 are in square pyramidal coordination, and the Co atoms in 2 are in octahedral coordination. The compounds were assayed against the bacterial strains Bacillus subtillis , Staphylococcus aureus , Escherichia coli , and Pseudomonas aereuguinosa. The Cu and Zn complexes have effective antibacterial activities. [Display omitted] • The aroylhydrazone compound N′ -(2-hydroxy-4-methoxybenzylidene)-3-methylbenzohydrazide was newly synthesized. • The three complexes were newly synthesized. • Single crystal structures of the aroylhydrazone compound and the complexes were first reported. • The complexes have potential antibacterial activities on the bacterial strains Bacillus subtillis , Staphylococcus aureus , Escherichia coli , and Pseudomonas aereuguinosa. [ABSTRACT FROM AUTHOR]
ISSN:	00201693
DOI:	10.1016/j.ica.2026.123094