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Bioactive S-PRG materials in dental applications: A clinical evidence–based scoping review.

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Title: Bioactive S-PRG materials in dental applications: A clinical evidence–based scoping review.
Authors: Ferreira, Nathan Felipini1 (AUTHOR), de Oliveira Alves, Renata2 (AUTHOR), de Toledo, Priscila Toninatto Alves3 (AUTHOR), Peres, Georgia Rondó2 (AUTHOR), Danelon, Marcelle4 (AUTHOR), Guiotti, Aimée Maria1 (AUTHOR), Nunes, Gabriel Pereira1,5 (AUTHOR) gabriel.nunesp94@gmail.com
Source: Dental Materials. Mar2026, Vol. 42 Issue 3, p512-532. 21p.
Subjects: Cavity prevention, Tooth sensitivity, Dentistry, Medical research, Operative dentistry, Biopolymers
Abstract: This scoping review (SR) aimed to map the clinical evidence on the effects of surface pre-reacted glass ionomer (S-PRG)-based materials on dental tissues and performance in restorative, preventive, and therapeutic applications. The SR followed the PRISMA-ScR statement, conducting a comprehensive search across multiple databases for articles published up to January 2025. Out of the 3914 records screened, 49 studies were included in the review. Clinical trials have demonstrated promising outcomes in various dental applications. In caries prevention and white spot lesion management, S-PRG-based sealants and varnishes showed bioactive effects, contributing to remineralization despite limitations in retention. In restorative treatments, S-PRG-based materials showed high clinical success rates, adequate marginal integrity, and minimal postoperative sensitivity, with performance similar to materials without S-PRG fillers. Favorable results were also observed in the treatment of non-carious cervical lesions, dentin hypersensitivity, and molar-incisor hypomineralization, reinforcing the versatility and clinical potential of S-PRG-containing materials. Based on findings, materials containing S-PRG fillers have demonstrated satisfactory clinical performance across various dental applications, especially as restorative agents, sealants, and desensitizers. However, further longer-term clinical studies are needed to confirm their durability, effectiveness over time, and optimize clinical application. [Display omitted] • S-PRG materials effectively prevent caries while supporting enamel remineralization. • S-PRG materials reduce dentin hypersensitivity with immediate and lasting relief. • Giomer restorations show high survival, minimal sensitivity, and good aesthetics. • S-PRG applications show potential in MIH management and other specialized dental treatments. • Long-term clinical trials are required to confirm durability and therapeutic effects. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
Description
Abstract:This scoping review (SR) aimed to map the clinical evidence on the effects of surface pre-reacted glass ionomer (S-PRG)-based materials on dental tissues and performance in restorative, preventive, and therapeutic applications. The SR followed the PRISMA-ScR statement, conducting a comprehensive search across multiple databases for articles published up to January 2025. Out of the 3914 records screened, 49 studies were included in the review. Clinical trials have demonstrated promising outcomes in various dental applications. In caries prevention and white spot lesion management, S-PRG-based sealants and varnishes showed bioactive effects, contributing to remineralization despite limitations in retention. In restorative treatments, S-PRG-based materials showed high clinical success rates, adequate marginal integrity, and minimal postoperative sensitivity, with performance similar to materials without S-PRG fillers. Favorable results were also observed in the treatment of non-carious cervical lesions, dentin hypersensitivity, and molar-incisor hypomineralization, reinforcing the versatility and clinical potential of S-PRG-containing materials. Based on findings, materials containing S-PRG fillers have demonstrated satisfactory clinical performance across various dental applications, especially as restorative agents, sealants, and desensitizers. However, further longer-term clinical studies are needed to confirm their durability, effectiveness over time, and optimize clinical application. [Display omitted] • S-PRG materials effectively prevent caries while supporting enamel remineralization. • S-PRG materials reduce dentin hypersensitivity with immediate and lasting relief. • Giomer restorations show high survival, minimal sensitivity, and good aesthetics. • S-PRG applications show potential in MIH management and other specialized dental treatments. • Long-term clinical trials are required to confirm durability and therapeutic effects. [ABSTRACT FROM AUTHOR]
ISSN:01095641
DOI:10.1016/j.dental.2025.11.012