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Bioactive S-PRG materials in dental applications: A clinical evidence–based scoping review.

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Title: Bioactive S-PRG materials in dental applications: A clinical evidence–based scoping review.
Authors: Ferreira, Nathan Felipini1 (AUTHOR), de Oliveira Alves, Renata2 (AUTHOR), de Toledo, Priscila Toninatto Alves3 (AUTHOR), Peres, Georgia Rondó2 (AUTHOR), Danelon, Marcelle4 (AUTHOR), Guiotti, Aimée Maria1 (AUTHOR), Nunes, Gabriel Pereira1,5 (AUTHOR) gabriel.nunesp94@gmail.com
Source: Dental Materials. Mar2026, Vol. 42 Issue 3, p512-532. 21p.
Subjects: Cavity prevention, Tooth sensitivity, Dentistry, Medical research, Operative dentistry, Biopolymers
Abstract: This scoping review (SR) aimed to map the clinical evidence on the effects of surface pre-reacted glass ionomer (S-PRG)-based materials on dental tissues and performance in restorative, preventive, and therapeutic applications. The SR followed the PRISMA-ScR statement, conducting a comprehensive search across multiple databases for articles published up to January 2025. Out of the 3914 records screened, 49 studies were included in the review. Clinical trials have demonstrated promising outcomes in various dental applications. In caries prevention and white spot lesion management, S-PRG-based sealants and varnishes showed bioactive effects, contributing to remineralization despite limitations in retention. In restorative treatments, S-PRG-based materials showed high clinical success rates, adequate marginal integrity, and minimal postoperative sensitivity, with performance similar to materials without S-PRG fillers. Favorable results were also observed in the treatment of non-carious cervical lesions, dentin hypersensitivity, and molar-incisor hypomineralization, reinforcing the versatility and clinical potential of S-PRG-containing materials. Based on findings, materials containing S-PRG fillers have demonstrated satisfactory clinical performance across various dental applications, especially as restorative agents, sealants, and desensitizers. However, further longer-term clinical studies are needed to confirm their durability, effectiveness over time, and optimize clinical application. [Display omitted] • S-PRG materials effectively prevent caries while supporting enamel remineralization. • S-PRG materials reduce dentin hypersensitivity with immediate and lasting relief. • Giomer restorations show high survival, minimal sensitivity, and good aesthetics. • S-PRG applications show potential in MIH management and other specialized dental treatments. • Long-term clinical trials are required to confirm durability and therapeutic effects. [ABSTRACT FROM AUTHOR]
Copyright of Dental Materials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
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PubType: Academic Journal
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  Data: Bioactive S-PRG materials in dental applications: A clinical evidence–based scoping review.
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  Data: <searchLink fieldCode="AR" term="%22Ferreira%2C+Nathan+Felipini%22">Ferreira, Nathan Felipini</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Oliveira+Alves%2C+Renata%22">de Oliveira Alves, Renata</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Toledo%2C+Priscila+Toninatto+Alves%22">de Toledo, Priscila Toninatto Alves</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Peres%2C+Georgia+Rondó%22">Peres, Georgia Rondó</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Danelon%2C+Marcelle%22">Danelon, Marcelle</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guiotti%2C+Aimée+Maria%22">Guiotti, Aimée Maria</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nunes%2C+Gabriel+Pereira%22">Nunes, Gabriel Pereira</searchLink><relatesTo>1,5</relatesTo> (AUTHOR)<i> gabriel.nunesp94@gmail.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Dental+Materials%22">Dental Materials</searchLink>. Mar2026, Vol. 42 Issue 3, p512-532. 21p.
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  Data: <searchLink fieldCode="DE" term="%22Cavity+prevention%22">Cavity prevention</searchLink><br /><searchLink fieldCode="DE" term="%22Tooth+sensitivity%22">Tooth sensitivity</searchLink><br /><searchLink fieldCode="DE" term="%22Dentistry%22">Dentistry</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+research%22">Medical research</searchLink><br /><searchLink fieldCode="DE" term="%22Operative+dentistry%22">Operative dentistry</searchLink><br /><searchLink fieldCode="DE" term="%22Biopolymers%22">Biopolymers</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: This scoping review (SR) aimed to map the clinical evidence on the effects of surface pre-reacted glass ionomer (S-PRG)-based materials on dental tissues and performance in restorative, preventive, and therapeutic applications. The SR followed the PRISMA-ScR statement, conducting a comprehensive search across multiple databases for articles published up to January 2025. Out of the 3914 records screened, 49 studies were included in the review. Clinical trials have demonstrated promising outcomes in various dental applications. In caries prevention and white spot lesion management, S-PRG-based sealants and varnishes showed bioactive effects, contributing to remineralization despite limitations in retention. In restorative treatments, S-PRG-based materials showed high clinical success rates, adequate marginal integrity, and minimal postoperative sensitivity, with performance similar to materials without S-PRG fillers. Favorable results were also observed in the treatment of non-carious cervical lesions, dentin hypersensitivity, and molar-incisor hypomineralization, reinforcing the versatility and clinical potential of S-PRG-containing materials. Based on findings, materials containing S-PRG fillers have demonstrated satisfactory clinical performance across various dental applications, especially as restorative agents, sealants, and desensitizers. However, further longer-term clinical studies are needed to confirm their durability, effectiveness over time, and optimize clinical application. [Display omitted] • S-PRG materials effectively prevent caries while supporting enamel remineralization. • S-PRG materials reduce dentin hypersensitivity with immediate and lasting relief. • Giomer restorations show high survival, minimal sensitivity, and good aesthetics. • S-PRG applications show potential in MIH management and other specialized dental treatments. • Long-term clinical trials are required to confirm durability and therapeutic effects. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Dental Materials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=191351175
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      – Type: doi
        Value: 10.1016/j.dental.2025.11.012
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      – Code: eng
        Text: English
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        PageCount: 21
        StartPage: 512
    Subjects:
      – SubjectFull: Cavity prevention
        Type: general
      – SubjectFull: Tooth sensitivity
        Type: general
      – SubjectFull: Dentistry
        Type: general
      – SubjectFull: Medical research
        Type: general
      – SubjectFull: Operative dentistry
        Type: general
      – SubjectFull: Biopolymers
        Type: general
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      – TitleFull: Bioactive S-PRG materials in dental applications: A clinical evidence–based scoping review.
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            NameFull: Ferreira, Nathan Felipini
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            NameFull: de Oliveira Alves, Renata
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            NameFull: de Toledo, Priscila Toninatto Alves
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            – D: 01
              M: 03
              Text: Mar2026
              Type: published
              Y: 2026
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