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Flexible steric bulk of sugar wingtip substituents on bis(N-heterocyclic carbene) ligands of diplatinum complexes via chair–twist-boat conformational changes.

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Bibliographic Details
Title:	Flexible steric bulk of sugar wingtip substituents on bis(N-heterocyclic carbene) ligands of diplatinum complexes via chair–twist-boat conformational changes.
Authors:	Nomura, Shuhei¹ (AUTHOR), Kobayashi, Itsuki¹ (AUTHOR), Doe, Matsumi² (AUTHOR), Tanaka, Rika² (AUTHOR), Nagasawa, Tamaki² (AUTHOR), Nishioka, Takanori¹ (AUTHOR) nishioka@omu.ac.jp
Source:	Dalton Transactions: An International Journal of Inorganic Chemistry. 2/24/2026, Vol. 55 Issue 8, p3542-3550. 9p.
Subjects:	Steric hindrance, Conformational analysis, Grignard reagents, Ligands (Chemistry), Metal complexes
Abstract:	In the p-toluenethiolate-bridged diplatinum complex bearing ethylene-bridged bis(N-heterocyclic carbene) ligands, all four acetyl-protected glucopyranosyl wingtip substituents adopt the chair conformation, giving rise to an open structure around the Pt2S2 core that allows the complex to react with a Grignard reagent. In contrast, in the corresponding diplatinum complex with o-xylene-bridged bis(N-heterocyclic carbene) ligands, two of the four acetyl-protected glucopyranosyl groups adopt the twist-boat conformation to relieve the steric repulsion among the wingtip N-substituents, resulting in a covered structure around the Pt2S2 core that inhibits reaction with a Grignard reagent. [ABSTRACT FROM AUTHOR]
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Database:	Engineering Source

Description
Abstract:	In the p-toluenethiolate-bridged diplatinum complex bearing ethylene-bridged bis(N-heterocyclic carbene) ligands, all four acetyl-protected glucopyranosyl wingtip substituents adopt the chair conformation, giving rise to an open structure around the Pt2S2 core that allows the complex to react with a Grignard reagent. In contrast, in the corresponding diplatinum complex with o-xylene-bridged bis(N-heterocyclic carbene) ligands, two of the four acetyl-protected glucopyranosyl groups adopt the twist-boat conformation to relieve the steric repulsion among the wingtip N-substituents, resulting in a covered structure around the Pt2S2 core that inhibits reaction with a Grignard reagent. [ABSTRACT FROM AUTHOR]
ISSN:	14779226
DOI:	10.1039/d6dt00111d