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Electrospun fibrous scaffolds reinforced with SCS-treated TiO2-based compounds: Novel investigation of visible light-induced bioactivity.

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Title: Electrospun fibrous scaffolds reinforced with SCS-treated TiO2-based compounds: Novel investigation of visible light-induced bioactivity.
Authors: Shahla, Mohaddeseh1 (AUTHOR), Mollazadeh Beidokhti, Sahar1 (AUTHOR) Mollazadeh.b@um.ac.ir, Vahdati Khaki, Jalil1 (AUTHOR)
Source: Ceramics International. Mar2026, Vol. 52 Issue 6, p7237-7260. 24p.
Subjects: Tissue scaffolds, Titanium compounds, Polymeric composites, Electrospinning, Biomineralization, Tissue engineering, Nanoparticles
Abstract: The present research focused on the fabrication of fibrous scaffolds loaded with titanate-based compounds as a candidate for the repairing of damaged soft tissues. The electrospinning process was used to produce a sandwich-like biocomposite with layers of PCL and PVA/gelatin on the face and core, respectively. MnTiO 3 , ZnTiO 3 , titanate-based compounds, were utilized to reinforce the polymeric mat. This study examines how visible light affects the biomineralization process on fibrous scaffolds with varying concentrations of MnTiO 3 (M1), ZnTiO 3 (Z1), and the 50:50 binary system (Z5M5). The mentioned titanate-based nanoparticles were produced by the solution combustion synthesis (SCS) method. XRD, FE-SEM, and TEM results indicated the chemical composition and morphology of nanoparticles, respectively. UV–vis diffuse reflectance spectroscopy (DRS) revealed band gap values in the range of 2.5–3.55 eV for the synthesized samples. The narrow band gap of the synthesized sample could provide the absorption possibility of visible light. Besides, the fabricated composite scaffolds were analyzed physically, mechanically, and biologically. FE-SEM images and water contact angle analysis revealed that a decrease in fiber diameter is associated with increased hydrophilicity in bead-free composite scaffolds. Besides, the presence of nanoparticles increased the Young's modulus of scaffolds up to 5.5 MPa. In vitro experiments, including the MTT assay, showed the cytocompatibility of all scaffolds. Moreover, the evaluation of the scaffolds under visible light proved the surface bioactivity after 2–4 weeks of immersion in SBF. As a result of the biomineralization process, the surface roughness of the optimal sample (ZH4W) increased to 296 nm after light irradiation in SBF. [ABSTRACT FROM AUTHOR]
Copyright of Ceramics International is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
An: 191815993
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  Data: Electrospun fibrous scaffolds reinforced with SCS-treated TiO2-based compounds: Novel investigation of visible light-induced bioactivity.
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  Data: <searchLink fieldCode="AR" term="%22Shahla%2C+Mohaddeseh%22">Shahla, Mohaddeseh</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mollazadeh+Beidokhti%2C+Sahar%22">Mollazadeh Beidokhti, Sahar</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> Mollazadeh.b@um.ac.ir</i><br /><searchLink fieldCode="AR" term="%22Vahdati+Khaki%2C+Jalil%22">Vahdati Khaki, Jalil</searchLink><relatesTo>1</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Ceramics+International%22">Ceramics International</searchLink>. Mar2026, Vol. 52 Issue 6, p7237-7260. 24p.
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  Data: <searchLink fieldCode="DE" term="%22Tissue+scaffolds%22">Tissue scaffolds</searchLink><br /><searchLink fieldCode="DE" term="%22Titanium+compounds%22">Titanium compounds</searchLink><br /><searchLink fieldCode="DE" term="%22Polymeric+composites%22">Polymeric composites</searchLink><br /><searchLink fieldCode="DE" term="%22Electrospinning%22">Electrospinning</searchLink><br /><searchLink fieldCode="DE" term="%22Biomineralization%22">Biomineralization</searchLink><br /><searchLink fieldCode="DE" term="%22Tissue+engineering%22">Tissue engineering</searchLink><br /><searchLink fieldCode="DE" term="%22Nanoparticles%22">Nanoparticles</searchLink>
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  Data: The present research focused on the fabrication of fibrous scaffolds loaded with titanate-based compounds as a candidate for the repairing of damaged soft tissues. The electrospinning process was used to produce a sandwich-like biocomposite with layers of PCL and PVA/gelatin on the face and core, respectively. MnTiO 3 , ZnTiO 3 , titanate-based compounds, were utilized to reinforce the polymeric mat. This study examines how visible light affects the biomineralization process on fibrous scaffolds with varying concentrations of MnTiO 3 (M1), ZnTiO 3 (Z1), and the 50:50 binary system (Z5M5). The mentioned titanate-based nanoparticles were produced by the solution combustion synthesis (SCS) method. XRD, FE-SEM, and TEM results indicated the chemical composition and morphology of nanoparticles, respectively. UV–vis diffuse reflectance spectroscopy (DRS) revealed band gap values in the range of 2.5–3.55 eV for the synthesized samples. The narrow band gap of the synthesized sample could provide the absorption possibility of visible light. Besides, the fabricated composite scaffolds were analyzed physically, mechanically, and biologically. FE-SEM images and water contact angle analysis revealed that a decrease in fiber diameter is associated with increased hydrophilicity in bead-free composite scaffolds. Besides, the presence of nanoparticles increased the Young's modulus of scaffolds up to 5.5 MPa. In vitro experiments, including the MTT assay, showed the cytocompatibility of all scaffolds. Moreover, the evaluation of the scaffolds under visible light proved the surface bioactivity after 2–4 weeks of immersion in SBF. As a result of the biomineralization process, the surface roughness of the optimal sample (ZH4W) increased to 296 nm after light irradiation in SBF. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Ceramics International is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.ceramint.2025.12.466
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      – Code: eng
        Text: English
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        Type: general
      – SubjectFull: Titanium compounds
        Type: general
      – SubjectFull: Polymeric composites
        Type: general
      – SubjectFull: Electrospinning
        Type: general
      – SubjectFull: Biomineralization
        Type: general
      – SubjectFull: Tissue engineering
        Type: general
      – SubjectFull: Nanoparticles
        Type: general
    Titles:
      – TitleFull: Electrospun fibrous scaffolds reinforced with SCS-treated TiO2-based compounds: Novel investigation of visible light-induced bioactivity.
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            NameFull: Shahla, Mohaddeseh
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            NameFull: Mollazadeh Beidokhti, Sahar
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            NameFull: Vahdati Khaki, Jalil
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            – D: 01
              M: 03
              Text: Mar2026
              Type: published
              Y: 2026
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            – TitleFull: Ceramics International
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