Bibliographic Details
| Title: |
Technical discussion on the methodological and interpretative aspects of "mineralized extracellular matrix composite scaffold incorporated with salvianolic acid a enhances bone marrow mesenchymal stem cell osteogenesis and promotes calvarial bone regeneration" |
| Authors: |
Silva, Luis F.O.1 (AUTHOR) lfsoacademico@gmail.com |
| Source: |
Biomaterials Advances. Jun2026, Vol. 183, pN.PAG-N.PAG. 1p. |
| Subjects: |
Extracellular matrix, Biomineralization, Salvia miltiorrhiza, Neovascularization, Calcium phosphate, Bone growth, Fourier transform infrared spectroscopy, X-ray powder diffraction |
| Abstract: |
• The term "mineralised extracellular matrix" is used without adequate crystallographic or nanoscale validation of true mineral phases. • Reported calcium phosphate deposition is consistent with ion adsorption or amorphous surface coatings, not true mineralisation. • Lack of intrafibrillar mineralisation and lattice-resolved imaging precludes claims of bone-like mineral architecture. • Qualitative XRD and FTIR data alone cannot establish crystallinity, phase purity, or mineral maturation pathways. • Osteogenic and angiogenic effects are confounded by scaffold properties, ion release, and salvianolic acid A bioactivity. • Crystallographic validation and mechanistic deconvolution are essential for accurate terminology and reproducibility. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
