Technical discussion on the methodological and interpretative aspects of "mineralized extracellular matrix composite scaffold incorporated with salvianolic acid a enhances bone marrow mesenchymal stem cell osteogenesis and promotes calvarial bone regeneration"
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| Title: | Technical discussion on the methodological and interpretative aspects of "mineralized extracellular matrix composite scaffold incorporated with salvianolic acid a enhances bone marrow mesenchymal stem cell osteogenesis and promotes calvarial bone regeneration" |
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| Authors: | Silva, Luis F.O.1 (AUTHOR) lfsoacademico@gmail.com |
| Source: | Biomaterials Advances. Jun2026, Vol. 183, pN.PAG-N.PAG. 1p. |
| Subjects: | Extracellular matrix, Biomineralization, Salvia miltiorrhiza, Neovascularization, Calcium phosphate, Bone growth, Fourier transform infrared spectroscopy, X-ray powder diffraction |
| Abstract: | • The term "mineralised extracellular matrix" is used without adequate crystallographic or nanoscale validation of true mineral phases. • Reported calcium phosphate deposition is consistent with ion adsorption or amorphous surface coatings, not true mineralisation. • Lack of intrafibrillar mineralisation and lattice-resolved imaging precludes claims of bone-like mineral architecture. • Qualitative XRD and FTIR data alone cannot establish crystallinity, phase purity, or mineral maturation pathways. • Osteogenic and angiogenic effects are confounded by scaffold properties, ion release, and salvianolic acid A bioactivity. • Crystallographic validation and mechanistic deconvolution are essential for accurate terminology and reproducibility. [ABSTRACT FROM AUTHOR] |
| Copyright of Biomaterials Advances is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 192004801 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Technical discussion on the methodological and interpretative aspects of "mineralized extracellular matrix composite scaffold incorporated with salvianolic acid a enhances bone marrow mesenchymal stem cell osteogenesis and promotes calvarial bone regeneration" – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Silva%2C+Luis+F%2EO%2E%22">Silva, Luis F.O.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> lfsoacademico@gmail.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Biomaterials+Advances%22">Biomaterials Advances</searchLink>. Jun2026, Vol. 183, pN.PAG-N.PAG. 1p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Extracellular+matrix%22">Extracellular matrix</searchLink><br /><searchLink fieldCode="DE" term="%22Biomineralization%22">Biomineralization</searchLink><br /><searchLink fieldCode="DE" term="%22Salvia+miltiorrhiza%22">Salvia miltiorrhiza</searchLink><br /><searchLink fieldCode="DE" term="%22Neovascularization%22">Neovascularization</searchLink><br /><searchLink fieldCode="DE" term="%22Calcium+phosphate%22">Calcium phosphate</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+growth%22">Bone growth</searchLink><br /><searchLink fieldCode="DE" term="%22Fourier+transform+infrared+spectroscopy%22">Fourier transform infrared spectroscopy</searchLink><br /><searchLink fieldCode="DE" term="%22X-ray+powder+diffraction%22">X-ray powder diffraction</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: • The term "mineralised extracellular matrix" is used without adequate crystallographic or nanoscale validation of true mineral phases. • Reported calcium phosphate deposition is consistent with ion adsorption or amorphous surface coatings, not true mineralisation. • Lack of intrafibrillar mineralisation and lattice-resolved imaging precludes claims of bone-like mineral architecture. • Qualitative XRD and FTIR data alone cannot establish crystallinity, phase purity, or mineral maturation pathways. • Osteogenic and angiogenic effects are confounded by scaffold properties, ion release, and salvianolic acid A bioactivity. • Crystallographic validation and mechanistic deconvolution are essential for accurate terminology and reproducibility. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Biomaterials Advances is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.bioadv.2026.214756 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: N.PAG Subjects: – SubjectFull: Extracellular matrix Type: general – SubjectFull: Biomineralization Type: general – SubjectFull: Salvia miltiorrhiza Type: general – SubjectFull: Neovascularization Type: general – SubjectFull: Calcium phosphate Type: general – SubjectFull: Bone growth Type: general – SubjectFull: Fourier transform infrared spectroscopy Type: general – SubjectFull: X-ray powder diffraction Type: general Titles: – TitleFull: Technical discussion on the methodological and interpretative aspects of "mineralized extracellular matrix composite scaffold incorporated with salvianolic acid a enhances bone marrow mesenchymal stem cell osteogenesis and promotes calvarial bone regeneration" Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Silva, Luis F.O. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 27729516 Numbering: – Type: volume Value: 183 Titles: – TitleFull: Biomaterials Advances Type: main |
| ResultId | 1 |
