View in EDS

Magnetic MOF-Based Immunosensing Strategy with Quantum Dot Labeling for Efficient Electro-chemiluminescent Detection of Alpha-fetoprotein.

Saved in:
Bibliographic Details
Title: Magnetic MOF-Based Immunosensing Strategy with Quantum Dot Labeling for Efficient Electro-chemiluminescent Detection of Alpha-fetoprotein.
Authors: Fatima, Mariyam1 (AUTHOR), Faizan, Muhammad1 (AUTHOR), Jabeen, Iqra2 (AUTHOR), Fiaz, Muhammad3 (AUTHOR), Ali, Ansar4 (AUTHOR), Ali, Syed Kashif5,6 (AUTHOR), Bahadur, Ali7,8 (AUTHOR) abahadur@wku.edu.cn, Iqbal, Shahid9 (AUTHOR) shahidgcs10@yahoo.com, Mahmood, Sajid10,11 (AUTHOR), Jafri, Ibrahim12 (AUTHOR), Farouk, Abd-ElAziem12 (AUTHOR)
Source: Journal of Fluorescence. Jan2026, Vol. 36 Issue 1, p921-934. 14p.
Subjects: Alpha fetoproteins, Electrochemiluminescence, Quantum dots, Immunostaining, Tumor markers, Metal-organic frameworks, Carbon nanodots
Abstract: This study presents the development of a highly sensitive and selective electrochemiluminescence (ECL) sandwich-type immunosensor for the detection of alpha-fetoprotein (AFP), a critical biomarker for early-stage liver cancer diagnosis. The sensor platform integrates a Fe-Ni-based metal-organic framework (MOF) with magnetic Fe₃O₄ nanoparticles (Fe-Ni-MOF), functionalized with primary antibodies (Ab1). Carbon quantum dots (CQDs) were conjugated with secondary antibodies (Ab2) to serve as ECL luminophores. The immunosensor demonstrated a wide linear detection range for AFP from 0.001 to 1000 ng/mL, with a low detection limit of 0.0084 ng/mL. Structural, morphological, thermal, and optical characterizations confirmed the successful synthesis and functionalization of the composite materials. Moreover, the fabricated sensor exhibited excellent reproducibility, specificity, and stability, indicating its potential as a practical tool for early cancer diagnostics in complex biological samples. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Fluorescence is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 192008093
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Magnetic MOF-Based Immunosensing Strategy with Quantum Dot Labeling for Efficient Electro-chemiluminescent Detection of Alpha-fetoprotein.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Fatima%2C+Mariyam%22">Fatima, Mariyam</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Faizan%2C+Muhammad%22">Faizan, Muhammad</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jabeen%2C+Iqra%22">Jabeen, Iqra</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fiaz%2C+Muhammad%22">Fiaz, Muhammad</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ali%2C+Ansar%22">Ali, Ansar</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ali%2C+Syed+Kashif%22">Ali, Syed Kashif</searchLink><relatesTo>5,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bahadur%2C+Ali%22">Bahadur, Ali</searchLink><relatesTo>7,8</relatesTo> (AUTHOR)<i> abahadur@wku.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Iqbal%2C+Shahid%22">Iqbal, Shahid</searchLink><relatesTo>9</relatesTo> (AUTHOR)<i> shahidgcs10@yahoo.com</i><br /><searchLink fieldCode="AR" term="%22Mahmood%2C+Sajid%22">Mahmood, Sajid</searchLink><relatesTo>10,11</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jafri%2C+Ibrahim%22">Jafri, Ibrahim</searchLink><relatesTo>12</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Farouk%2C+Abd-ElAziem%22">Farouk, Abd-ElAziem</searchLink><relatesTo>12</relatesTo> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Journal+of+Fluorescence%22">Journal of Fluorescence</searchLink>. Jan2026, Vol. 36 Issue 1, p921-934. 14p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Alpha+fetoproteins%22">Alpha fetoproteins</searchLink><br /><searchLink fieldCode="DE" term="%22Electrochemiluminescence%22">Electrochemiluminescence</searchLink><br /><searchLink fieldCode="DE" term="%22Quantum+dots%22">Quantum dots</searchLink><br /><searchLink fieldCode="DE" term="%22Immunostaining%22">Immunostaining</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+markers%22">Tumor markers</searchLink><br /><searchLink fieldCode="DE" term="%22Metal-organic+frameworks%22">Metal-organic frameworks</searchLink><br /><searchLink fieldCode="DE" term="%22Carbon+nanodots%22">Carbon nanodots</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: This study presents the development of a highly sensitive and selective electrochemiluminescence (ECL) sandwich-type immunosensor for the detection of alpha-fetoprotein (AFP), a critical biomarker for early-stage liver cancer diagnosis. The sensor platform integrates a Fe-Ni-based metal-organic framework (MOF) with magnetic Fe₃O₄ nanoparticles (Fe-Ni-MOF), functionalized with primary antibodies (Ab1). Carbon quantum dots (CQDs) were conjugated with secondary antibodies (Ab2) to serve as ECL luminophores. The immunosensor demonstrated a wide linear detection range for AFP from 0.001 to 1000 ng/mL, with a low detection limit of 0.0084 ng/mL. Structural, morphological, thermal, and optical characterizations confirmed the successful synthesis and functionalization of the composite materials. Moreover, the fabricated sensor exhibited excellent reproducibility, specificity, and stability, indicating its potential as a practical tool for early cancer diagnostics in complex biological samples. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Fluorescence is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=192008093
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s10895-025-04616-0
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 14
        StartPage: 921
    Subjects:
      – SubjectFull: Alpha fetoproteins
        Type: general
      – SubjectFull: Electrochemiluminescence
        Type: general
      – SubjectFull: Quantum dots
        Type: general
      – SubjectFull: Immunostaining
        Type: general
      – SubjectFull: Tumor markers
        Type: general
      – SubjectFull: Metal-organic frameworks
        Type: general
      – SubjectFull: Carbon nanodots
        Type: general
    Titles:
      – TitleFull: Magnetic MOF-Based Immunosensing Strategy with Quantum Dot Labeling for Efficient Electro-chemiluminescent Detection of Alpha-fetoprotein.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Fatima, Mariyam
      – PersonEntity:
          Name:
            NameFull: Faizan, Muhammad
      – PersonEntity:
          Name:
            NameFull: Jabeen, Iqra
      – PersonEntity:
          Name:
            NameFull: Fiaz, Muhammad
      – PersonEntity:
          Name:
            NameFull: Ali, Ansar
      – PersonEntity:
          Name:
            NameFull: Ali, Syed Kashif
      – PersonEntity:
          Name:
            NameFull: Bahadur, Ali
      – PersonEntity:
          Name:
            NameFull: Iqbal, Shahid
      – PersonEntity:
          Name:
            NameFull: Mahmood, Sajid
      – PersonEntity:
          Name:
            NameFull: Jafri, Ibrahim
      – PersonEntity:
          Name:
            NameFull: Farouk, Abd-ElAziem
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Text: Jan2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 10530509
          Numbering:
            – Type: volume
              Value: 36
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Journal of Fluorescence
              Type: main
ResultId 1