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Bioactive sericin scaffolds with allantoin-acetamide eutectic for enhanced wound healing.

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Title: Bioactive sericin scaffolds with allantoin-acetamide eutectic for enhanced wound healing.
Authors: Naseer, Muhammad1 (AUTHOR), Ali, Nawab2 (AUTHOR), Bibi, Iram1 (AUTHOR), Hussain Shah, Syed Waqar1 (AUTHOR), Rasheed, Liaqat3 (AUTHOR), Rehman, Wajid1 (AUTHOR) sono_waj@yahoo.com, Alzahrani, Abdullah Y.4 (AUTHOR), Abid, Obaid-Ur-Rahman1 (AUTHOR)
Source: Pure & Applied Chemistry. Mar2026, Vol. 98 Issue 3, p497-515. 19p.
Subjects: Wound healing, Sericin, Biomimetic materials, Binary mixtures, Acetamide, Drug delivery systems, Regeneration (Biology)
Abstract: Smart wound dressings that respond to the wound environment have emerged as innovative therapeutic platforms, aiming to control infection, reduce inflammation, and promote vascularization for effective healing. Herein, an innovative eutectic system combining acetamide and allantoin (AAM) integrated with sericin peptides (SS) for enhanced wound healing applications is reported. The binary AAM system exhibited superior physicochemical properties, utilizing acetamide's anti-inflammatory effects and allantoin's regenerative capabilities. The binary AAM system exhibited superior physicochemical properties, with molecular modeling revealing optimal donor-acceptor interactions and FTIR confirming complex intermolecular networks in SS-incorporated scaffolds. The SS-containing scaffolds showed significantly enhanced wound healing efficacy in a mouse model compared to non-functionalized AAM systems, with accelerated wound closure through synergistic interactions. This integration of eutectic systems with bioactive peptides presents a promising platform for advanced wound healing therapeutics, offering improved drug delivery and tissue regeneration. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
Description
Abstract:Smart wound dressings that respond to the wound environment have emerged as innovative therapeutic platforms, aiming to control infection, reduce inflammation, and promote vascularization for effective healing. Herein, an innovative eutectic system combining acetamide and allantoin (AAM) integrated with sericin peptides (SS) for enhanced wound healing applications is reported. The binary AAM system exhibited superior physicochemical properties, utilizing acetamide's anti-inflammatory effects and allantoin's regenerative capabilities. The binary AAM system exhibited superior physicochemical properties, with molecular modeling revealing optimal donor-acceptor interactions and FTIR confirming complex intermolecular networks in SS-incorporated scaffolds. The SS-containing scaffolds showed significantly enhanced wound healing efficacy in a mouse model compared to non-functionalized AAM systems, with accelerated wound closure through synergistic interactions. This integration of eutectic systems with bioactive peptides presents a promising platform for advanced wound healing therapeutics, offering improved drug delivery and tissue regeneration. [ABSTRACT FROM AUTHOR]
ISSN:00334545
DOI:10.1515/pac-2025-0519