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Bioactive sericin scaffolds with allantoin-acetamide eutectic for enhanced wound healing.

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Title: Bioactive sericin scaffolds with allantoin-acetamide eutectic for enhanced wound healing.
Authors: Naseer, Muhammad1 (AUTHOR), Ali, Nawab2 (AUTHOR), Bibi, Iram1 (AUTHOR), Hussain Shah, Syed Waqar1 (AUTHOR), Rasheed, Liaqat3 (AUTHOR), Rehman, Wajid1 (AUTHOR) sono_waj@yahoo.com, Alzahrani, Abdullah Y.4 (AUTHOR), Abid, Obaid-Ur-Rahman1 (AUTHOR)
Source: Pure & Applied Chemistry. Mar2026, Vol. 98 Issue 3, p497-515. 19p.
Subjects: Wound healing, Sericin, Biomimetic materials, Binary mixtures, Acetamide, Drug delivery systems, Regeneration (Biology)
Abstract: Smart wound dressings that respond to the wound environment have emerged as innovative therapeutic platforms, aiming to control infection, reduce inflammation, and promote vascularization for effective healing. Herein, an innovative eutectic system combining acetamide and allantoin (AAM) integrated with sericin peptides (SS) for enhanced wound healing applications is reported. The binary AAM system exhibited superior physicochemical properties, utilizing acetamide's anti-inflammatory effects and allantoin's regenerative capabilities. The binary AAM system exhibited superior physicochemical properties, with molecular modeling revealing optimal donor-acceptor interactions and FTIR confirming complex intermolecular networks in SS-incorporated scaffolds. The SS-containing scaffolds showed significantly enhanced wound healing efficacy in a mouse model compared to non-functionalized AAM systems, with accelerated wound closure through synergistic interactions. This integration of eutectic systems with bioactive peptides presents a promising platform for advanced wound healing therapeutics, offering improved drug delivery and tissue regeneration. [ABSTRACT FROM AUTHOR]
Copyright of Pure & Applied Chemistry is the property of De Gruyter and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
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DbLabel: Engineering Source
An: 192011356
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Bioactive sericin scaffolds with allantoin-acetamide eutectic for enhanced wound healing.
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  Data: <searchLink fieldCode="AR" term="%22Naseer%2C+Muhammad%22">Naseer, Muhammad</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ali%2C+Nawab%22">Ali, Nawab</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bibi%2C+Iram%22">Bibi, Iram</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hussain+Shah%2C+Syed+Waqar%22">Hussain Shah, Syed Waqar</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rasheed%2C+Liaqat%22">Rasheed, Liaqat</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rehman%2C+Wajid%22">Rehman, Wajid</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> sono_waj@yahoo.com</i><br /><searchLink fieldCode="AR" term="%22Alzahrani%2C+Abdullah+Y%2E%22">Alzahrani, Abdullah Y.</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Abid%2C+Obaid-Ur-Rahman%22">Abid, Obaid-Ur-Rahman</searchLink><relatesTo>1</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Pure+%26+Applied+Chemistry%22">Pure & Applied Chemistry</searchLink>. Mar2026, Vol. 98 Issue 3, p497-515. 19p.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Wound+healing%22">Wound healing</searchLink><br /><searchLink fieldCode="DE" term="%22Sericin%22">Sericin</searchLink><br /><searchLink fieldCode="DE" term="%22Biomimetic+materials%22">Biomimetic materials</searchLink><br /><searchLink fieldCode="DE" term="%22Binary+mixtures%22">Binary mixtures</searchLink><br /><searchLink fieldCode="DE" term="%22Acetamide%22">Acetamide</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+delivery+systems%22">Drug delivery systems</searchLink><br /><searchLink fieldCode="DE" term="%22Regeneration+%28Biology%29%22">Regeneration (Biology)</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Smart wound dressings that respond to the wound environment have emerged as innovative therapeutic platforms, aiming to control infection, reduce inflammation, and promote vascularization for effective healing. Herein, an innovative eutectic system combining acetamide and allantoin (AAM) integrated with sericin peptides (SS) for enhanced wound healing applications is reported. The binary AAM system exhibited superior physicochemical properties, utilizing acetamide's anti-inflammatory effects and allantoin's regenerative capabilities. The binary AAM system exhibited superior physicochemical properties, with molecular modeling revealing optimal donor-acceptor interactions and FTIR confirming complex intermolecular networks in SS-incorporated scaffolds. The SS-containing scaffolds showed significantly enhanced wound healing efficacy in a mouse model compared to non-functionalized AAM systems, with accelerated wound closure through synergistic interactions. This integration of eutectic systems with bioactive peptides presents a promising platform for advanced wound healing therapeutics, offering improved drug delivery and tissue regeneration. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Pure & Applied Chemistry is the property of De Gruyter and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1515/pac-2025-0519
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      – Code: eng
        Text: English
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        PageCount: 19
        StartPage: 497
    Subjects:
      – SubjectFull: Wound healing
        Type: general
      – SubjectFull: Sericin
        Type: general
      – SubjectFull: Biomimetic materials
        Type: general
      – SubjectFull: Binary mixtures
        Type: general
      – SubjectFull: Acetamide
        Type: general
      – SubjectFull: Drug delivery systems
        Type: general
      – SubjectFull: Regeneration (Biology)
        Type: general
    Titles:
      – TitleFull: Bioactive sericin scaffolds with allantoin-acetamide eutectic for enhanced wound healing.
        Type: main
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            NameFull: Naseer, Muhammad
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            NameFull: Ali, Nawab
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            NameFull: Bibi, Iram
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            NameFull: Hussain Shah, Syed Waqar
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            NameFull: Rasheed, Liaqat
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            – D: 01
              M: 03
              Text: Mar2026
              Type: published
              Y: 2026
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              Value: 00334545
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              Value: 98
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            – TitleFull: Pure & Applied Chemistry
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