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Construction and application of magnetic molecularly imprinted polymers for the analysis of florfenicol residues in fish meat.

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Title: Construction and application of magnetic molecularly imprinted polymers for the analysis of florfenicol residues in fish meat.
Authors: Gao, Hangfei1,2,3 (AUTHOR) gaohangfei5115@163.com, Yao, Boxuan1,2,3 (AUTHOR) yaobox2626@163.com, Liu, Zhicen1,2,4 (AUTHOR) l13394691497@163.com, Du, Yefeng5 (AUTHOR) duyefeng1979@126.com, Cheng, Long1,2,3 (AUTHOR) CCChengLLL210682@163.com, Bai, Shuyan1,2 (AUTHOR) baishuyan@hrfri.ac.cn, Li, Chenhui1,2 (AUTHOR) lichenhui@hrfri.ac.cn, Zhao, Honghua6 (AUTHOR) lyyzhh0515@163.com, Sun, Yueping7 (AUTHOR) 13945090574@163.com, Wang, Aiming8 (AUTHOR) blueseawam@ycit.cn, Qin, Dongli1,2,9 (AUTHOR) qindongli@hrfri.ac.cn, Huang, Li1,2 (AUTHOR) huangli@hrfri.ac.cn, Gao, Lei1,2,9 (AUTHOR) gaolei@hrfri.ac.cn
Source: Journal of Chromatography A. May2026, Vol. 1775, pN.PAG-N.PAG. 1p.
Subjects: Imprinted polymers, Veterinary drug residues, Carbon nanotubes, Solid phase extraction, Veterinary drugs, Liquid chromatography-mass spectrometry, Food safety, Drug residues
Abstract: • MSPE enables rapid dispersion and efficient enrichment of florfenicol in solution. • Using dummy templates minimizes template leakage and reduces false positives. • The synthesized MIPs showed high selectivity and specific recognition of florfenicol. • Carbon nanotubes provide high surface area, enhancing adsorption efficiency. • Integration of nanomaterials and MIPs shows promise in drug residue detection. Based on the concept of efficient and rapid detection, a carbon nanotube-based magnetic molecularly imprinted polymer was developed in this study. A series of characterization techniques were employed to investigate the structure and morphology of the material. The adsorption performance was investigated using static and dynamic adsorption experiments as well as selectivity tests, demonstrating that the imprinted layer was uniform and structurally stable. Adsorption experiments indicated that the material had significant advantages in binding capacity and selective recognition, effectively distinguishing florfenicol and its structural analogs. By combining magnetic solid-phase extraction with high-performance liquid chromatography–tandem mass spectrometry, an efficient detection method for florfenicol in fish meat samples was established. Methodological validation demonstrated a limit of detection of 1.65 ng/kg, a limit of quantification of 5.00 ng/kg, recovery rates of 90.3 %–111 %, standard deviations of 0.470 %–6.20 %, and relative standard deviations of 0.490 %–6.25 %. The results indicated that the prepared magnetic molecularly imprinted polymers not only achieved efficient detection of florfenicol but also provided a feasible new approach for monitoring veterinary drug residues in aquaculture, which is important for safeguarding food safety and public health. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
Description
Abstract:• MSPE enables rapid dispersion and efficient enrichment of florfenicol in solution. • Using dummy templates minimizes template leakage and reduces false positives. • The synthesized MIPs showed high selectivity and specific recognition of florfenicol. • Carbon nanotubes provide high surface area, enhancing adsorption efficiency. • Integration of nanomaterials and MIPs shows promise in drug residue detection. Based on the concept of efficient and rapid detection, a carbon nanotube-based magnetic molecularly imprinted polymer was developed in this study. A series of characterization techniques were employed to investigate the structure and morphology of the material. The adsorption performance was investigated using static and dynamic adsorption experiments as well as selectivity tests, demonstrating that the imprinted layer was uniform and structurally stable. Adsorption experiments indicated that the material had significant advantages in binding capacity and selective recognition, effectively distinguishing florfenicol and its structural analogs. By combining magnetic solid-phase extraction with high-performance liquid chromatography–tandem mass spectrometry, an efficient detection method for florfenicol in fish meat samples was established. Methodological validation demonstrated a limit of detection of 1.65 ng/kg, a limit of quantification of 5.00 ng/kg, recovery rates of 90.3 %–111 %, standard deviations of 0.470 %–6.20 %, and relative standard deviations of 0.490 %–6.25 %. The results indicated that the prepared magnetic molecularly imprinted polymers not only achieved efficient detection of florfenicol but also provided a feasible new approach for monitoring veterinary drug residues in aquaculture, which is important for safeguarding food safety and public health. [ABSTRACT FROM AUTHOR]
ISSN:00219673
DOI:10.1016/j.chroma.2026.466934