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Construction and application of magnetic molecularly imprinted polymers for the analysis of florfenicol residues in fish meat.

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Title: Construction and application of magnetic molecularly imprinted polymers for the analysis of florfenicol residues in fish meat.
Authors: Gao, Hangfei1,2,3 (AUTHOR) gaohangfei5115@163.com, Yao, Boxuan1,2,3 (AUTHOR) yaobox2626@163.com, Liu, Zhicen1,2,4 (AUTHOR) l13394691497@163.com, Du, Yefeng5 (AUTHOR) duyefeng1979@126.com, Cheng, Long1,2,3 (AUTHOR) CCChengLLL210682@163.com, Bai, Shuyan1,2 (AUTHOR) baishuyan@hrfri.ac.cn, Li, Chenhui1,2 (AUTHOR) lichenhui@hrfri.ac.cn, Zhao, Honghua6 (AUTHOR) lyyzhh0515@163.com, Sun, Yueping7 (AUTHOR) 13945090574@163.com, Wang, Aiming8 (AUTHOR) blueseawam@ycit.cn, Qin, Dongli1,2,9 (AUTHOR) qindongli@hrfri.ac.cn, Huang, Li1,2 (AUTHOR) huangli@hrfri.ac.cn, Gao, Lei1,2,9 (AUTHOR) gaolei@hrfri.ac.cn
Source: Journal of Chromatography A. May2026, Vol. 1775, pN.PAG-N.PAG. 1p.
Subjects: Imprinted polymers, Veterinary drug residues, Carbon nanotubes, Solid phase extraction, Veterinary drugs, Liquid chromatography-mass spectrometry, Food safety, Drug residues
Abstract: • MSPE enables rapid dispersion and efficient enrichment of florfenicol in solution. • Using dummy templates minimizes template leakage and reduces false positives. • The synthesized MIPs showed high selectivity and specific recognition of florfenicol. • Carbon nanotubes provide high surface area, enhancing adsorption efficiency. • Integration of nanomaterials and MIPs shows promise in drug residue detection. Based on the concept of efficient and rapid detection, a carbon nanotube-based magnetic molecularly imprinted polymer was developed in this study. A series of characterization techniques were employed to investigate the structure and morphology of the material. The adsorption performance was investigated using static and dynamic adsorption experiments as well as selectivity tests, demonstrating that the imprinted layer was uniform and structurally stable. Adsorption experiments indicated that the material had significant advantages in binding capacity and selective recognition, effectively distinguishing florfenicol and its structural analogs. By combining magnetic solid-phase extraction with high-performance liquid chromatography–tandem mass spectrometry, an efficient detection method for florfenicol in fish meat samples was established. Methodological validation demonstrated a limit of detection of 1.65 ng/kg, a limit of quantification of 5.00 ng/kg, recovery rates of 90.3 %–111 %, standard deviations of 0.470 %–6.20 %, and relative standard deviations of 0.490 %–6.25 %. The results indicated that the prepared magnetic molecularly imprinted polymers not only achieved efficient detection of florfenicol but also provided a feasible new approach for monitoring veterinary drug residues in aquaculture, which is important for safeguarding food safety and public health. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Chromatography A is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 192693144
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Construction and application of magnetic molecularly imprinted polymers for the analysis of florfenicol residues in fish meat.
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  Data: <searchLink fieldCode="AR" term="%22Gao%2C+Hangfei%22">Gao, Hangfei</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<i> gaohangfei5115@163.com</i><br /><searchLink fieldCode="AR" term="%22Yao%2C+Boxuan%22">Yao, Boxuan</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<i> yaobox2626@163.com</i><br /><searchLink fieldCode="AR" term="%22Liu%2C+Zhicen%22">Liu, Zhicen</searchLink><relatesTo>1,2,4</relatesTo> (AUTHOR)<i> l13394691497@163.com</i><br /><searchLink fieldCode="AR" term="%22Du%2C+Yefeng%22">Du, Yefeng</searchLink><relatesTo>5</relatesTo> (AUTHOR)<i> duyefeng1979@126.com</i><br /><searchLink fieldCode="AR" term="%22Cheng%2C+Long%22">Cheng, Long</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<i> CCChengLLL210682@163.com</i><br /><searchLink fieldCode="AR" term="%22Bai%2C+Shuyan%22">Bai, Shuyan</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> baishuyan@hrfri.ac.cn</i><br /><searchLink fieldCode="AR" term="%22Li%2C+Chenhui%22">Li, Chenhui</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> lichenhui@hrfri.ac.cn</i><br /><searchLink fieldCode="AR" term="%22Zhao%2C+Honghua%22">Zhao, Honghua</searchLink><relatesTo>6</relatesTo> (AUTHOR)<i> lyyzhh0515@163.com</i><br /><searchLink fieldCode="AR" term="%22Sun%2C+Yueping%22">Sun, Yueping</searchLink><relatesTo>7</relatesTo> (AUTHOR)<i> 13945090574@163.com</i><br /><searchLink fieldCode="AR" term="%22Wang%2C+Aiming%22">Wang, Aiming</searchLink><relatesTo>8</relatesTo> (AUTHOR)<i> blueseawam@ycit.cn</i><br /><searchLink fieldCode="AR" term="%22Qin%2C+Dongli%22">Qin, Dongli</searchLink><relatesTo>1,2,9</relatesTo> (AUTHOR)<i> qindongli@hrfri.ac.cn</i><br /><searchLink fieldCode="AR" term="%22Huang%2C+Li%22">Huang, Li</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> huangli@hrfri.ac.cn</i><br /><searchLink fieldCode="AR" term="%22Gao%2C+Lei%22">Gao, Lei</searchLink><relatesTo>1,2,9</relatesTo> (AUTHOR)<i> gaolei@hrfri.ac.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Chromatography+A%22">Journal of Chromatography A</searchLink>. May2026, Vol. 1775, pN.PAG-N.PAG. 1p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Imprinted+polymers%22">Imprinted polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Veterinary+drug+residues%22">Veterinary drug residues</searchLink><br /><searchLink fieldCode="DE" term="%22Carbon+nanotubes%22">Carbon nanotubes</searchLink><br /><searchLink fieldCode="DE" term="%22Solid+phase+extraction%22">Solid phase extraction</searchLink><br /><searchLink fieldCode="DE" term="%22Veterinary+drugs%22">Veterinary drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Liquid+chromatography-mass+spectrometry%22">Liquid chromatography-mass spectrometry</searchLink><br /><searchLink fieldCode="DE" term="%22Food+safety%22">Food safety</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+residues%22">Drug residues</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: • MSPE enables rapid dispersion and efficient enrichment of florfenicol in solution. • Using dummy templates minimizes template leakage and reduces false positives. • The synthesized MIPs showed high selectivity and specific recognition of florfenicol. • Carbon nanotubes provide high surface area, enhancing adsorption efficiency. • Integration of nanomaterials and MIPs shows promise in drug residue detection. Based on the concept of efficient and rapid detection, a carbon nanotube-based magnetic molecularly imprinted polymer was developed in this study. A series of characterization techniques were employed to investigate the structure and morphology of the material. The adsorption performance was investigated using static and dynamic adsorption experiments as well as selectivity tests, demonstrating that the imprinted layer was uniform and structurally stable. Adsorption experiments indicated that the material had significant advantages in binding capacity and selective recognition, effectively distinguishing florfenicol and its structural analogs. By combining magnetic solid-phase extraction with high-performance liquid chromatography–tandem mass spectrometry, an efficient detection method for florfenicol in fish meat samples was established. Methodological validation demonstrated a limit of detection of 1.65 ng/kg, a limit of quantification of 5.00 ng/kg, recovery rates of 90.3 %–111 %, standard deviations of 0.470 %–6.20 %, and relative standard deviations of 0.490 %–6.25 %. The results indicated that the prepared magnetic molecularly imprinted polymers not only achieved efficient detection of florfenicol but also provided a feasible new approach for monitoring veterinary drug residues in aquaculture, which is important for safeguarding food safety and public health. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Chromatography A is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.chroma.2026.466934
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Imprinted polymers
        Type: general
      – SubjectFull: Veterinary drug residues
        Type: general
      – SubjectFull: Carbon nanotubes
        Type: general
      – SubjectFull: Solid phase extraction
        Type: general
      – SubjectFull: Veterinary drugs
        Type: general
      – SubjectFull: Liquid chromatography-mass spectrometry
        Type: general
      – SubjectFull: Food safety
        Type: general
      – SubjectFull: Drug residues
        Type: general
    Titles:
      – TitleFull: Construction and application of magnetic molecularly imprinted polymers for the analysis of florfenicol residues in fish meat.
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              Text: May2026
              Type: published
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