Ailanthus altissima Extract Ameliorates Cognitive Decline and Neurodegeneration in an Aluminum Chloride–Induced Rat Model of Alzheimer's Disease.
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| Title: | Ailanthus altissima Extract Ameliorates Cognitive Decline and Neurodegeneration in an Aluminum Chloride–Induced Rat Model of Alzheimer's Disease. |
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| Authors: | Gravandi, Mohammad Mehdi1,2 (AUTHOR), Elieh-Ali-Komi, Daniel3,4 (AUTHOR), Amirian, Roshanak2 (AUTHOR), Hosseini, Seyede Zahra1 (AUTHOR), Alavi, Seyede Darya1 (AUTHOR), Shirooie, Samira1 (AUTHOR), Kiani, Amir1 (AUTHOR) akiani@kums.ac.ir, Farzaei, Mohammad Hosein1 (AUTHOR) mh_farzaei@kums.ac.ir, Bose, Anupama (AUTHOR) abose@wiley.com |
| Source: | Journal of Food Biochemistry. 4/3/2026, Vol. 2026, p1-10. 10p. |
| Subjects: | Alzheimer's disease, Neurodegeneration, Amyloid beta-protein, Neuroprotective agents, Aluminum chloride, Animal disease models, Cognition disorders |
| Abstract: | Background: The extract of Ailanthus altissima possesses anti‐inflammatory and neuroprotective properties. We aimed to investigate its effectiveness in mitigating the AlCl3‐induced Alzheimer's disease in a rat model. Methods: A total of 32 adult male Wistar rats were divided into 4 groups each consisting of 8 rats. The control group received saline and the AlCl3 group received AlCl3 (0.2 cc 100 mg/kg, intraperitoneal) for 14 days. Two other groups received either 50 or 100 mg/kg of Ailanthus altissima after AlCl3 treatment. Behavioral tests including open field test (OFT), elevated plus maze, and passive avoidance tests were performed. Nuclear factor kappa B (NF‐κB), glial filamentous acidic protein (GFAP), and amyloid beta were stained using immunohistochemistry (IHC) in the hippocampus. Results: AlCl3 administration caused significant memory impairment, and treatment with Ailanthus altissima extract effectively mitigated these deficits in a dose‐dependent manner. The effects were dose‐dependent, and the group receiving 100 mg/kg extract presented the most significant results in the conducted behavioral tests. The IHC results for NF‐κB showed that treatment with 50 mg/kg of extract significantly reduced NF‐κB expression compared with the AlCl3 group (6.64% vs. 13.3%, respectively, p < 0.05). A higher dose of 100 mg/kg resulted in an even greater reduction (4.45% vs. 13.3%, p < 0.01). Extract treatment reduced GFAP positivity in a dose‐dependent manner, with the 50 mg/kg group showing a significant decrease to 11.8% (p < 0.05). The 100 mg/kg group demonstrated an even more substantial reduction to 7.7% (p < 0.01) compared with the AlCl3 group (18.65%). Amyloid beta positivity was critically reduced in the 100 mg/kg‐receiving group. Conclusions: Ailanthus altissima extract shows potential as a neuroprotective extract. It counteracts AlCl3‐induced behavioral and neuropathological changes, suggesting promising therapeutic applications. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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| Abstract: | Background: The extract of Ailanthus altissima possesses anti‐inflammatory and neuroprotective properties. We aimed to investigate its effectiveness in mitigating the AlCl3‐induced Alzheimer's disease in a rat model. Methods: A total of 32 adult male Wistar rats were divided into 4 groups each consisting of 8 rats. The control group received saline and the AlCl3 group received AlCl3 (0.2 cc 100 mg/kg, intraperitoneal) for 14 days. Two other groups received either 50 or 100 mg/kg of Ailanthus altissima after AlCl3 treatment. Behavioral tests including open field test (OFT), elevated plus maze, and passive avoidance tests were performed. Nuclear factor kappa B (NF‐κB), glial filamentous acidic protein (GFAP), and amyloid beta were stained using immunohistochemistry (IHC) in the hippocampus. Results: AlCl3 administration caused significant memory impairment, and treatment with Ailanthus altissima extract effectively mitigated these deficits in a dose‐dependent manner. The effects were dose‐dependent, and the group receiving 100 mg/kg extract presented the most significant results in the conducted behavioral tests. The IHC results for NF‐κB showed that treatment with 50 mg/kg of extract significantly reduced NF‐κB expression compared with the AlCl3 group (6.64% vs. 13.3%, respectively, p < 0.05). A higher dose of 100 mg/kg resulted in an even greater reduction (4.45% vs. 13.3%, p < 0.01). Extract treatment reduced GFAP positivity in a dose‐dependent manner, with the 50 mg/kg group showing a significant decrease to 11.8% (p < 0.05). The 100 mg/kg group demonstrated an even more substantial reduction to 7.7% (p < 0.01) compared with the AlCl3 group (18.65%). Amyloid beta positivity was critically reduced in the 100 mg/kg‐receiving group. Conclusions: Ailanthus altissima extract shows potential as a neuroprotective extract. It counteracts AlCl3‐induced behavioral and neuropathological changes, suggesting promising therapeutic applications. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 01458884 |
| DOI: | 10.1155/jfbc/7471140 |
