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Advancements of polymersomes in drug delivery systems.

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Bibliographic Details
Title: Advancements of polymersomes in drug delivery systems.
Authors: Yang, Zhuang1 (AUTHOR), Xiong, Xiang Yuan1 (AUTHOR) xy.xiong@qq.com
Source: Journal of Macromolecular Science: Pure & Applied Chemistry. 2026, Vol. 63 Issue 5, p375-395. 21p.
Subjects: Polymersomes, Drug delivery systems, Targeted drug delivery, Pharmaceutical encapsulation, Block copolymers, Nanomedicine, Genome editing, Infection prevention
Abstract: Polymersomes, self-assembled from amphiphilic block copolymers, are nanoscale vesicles with a hydrophilic core and a hydrophobic bilayer. This unique structure allows them to efficiently encapsulate both hydrophilic and hydrophobic drugs, enabling co-delivery and synergistic therapeutic effects. This review systematically summarized their preparation methods, drug loading strategies, and functionalization approaches, highlighting recent applications in tumor-targeted therapy, gene editing, and anti-infection treatment. Despite ongoing challenges in scalable production, quality control, and clinical translation, polymersomes represent a promising intelligent platform for nano drug delivery with significant potential to enhance the treatment efficacy of drugs and reduce their side effects. HIGHLIGHTS: Polymersomes encapsulate both hydrophilic/hydrophobic drugs for synergy. Progress in their preparation, loading, and functionalization is summarized. Key applications in tumor therapy, gene editing, and anti-infection are highlighted. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
Description
Abstract:Polymersomes, self-assembled from amphiphilic block copolymers, are nanoscale vesicles with a hydrophilic core and a hydrophobic bilayer. This unique structure allows them to efficiently encapsulate both hydrophilic and hydrophobic drugs, enabling co-delivery and synergistic therapeutic effects. This review systematically summarized their preparation methods, drug loading strategies, and functionalization approaches, highlighting recent applications in tumor-targeted therapy, gene editing, and anti-infection treatment. Despite ongoing challenges in scalable production, quality control, and clinical translation, polymersomes represent a promising intelligent platform for nano drug delivery with significant potential to enhance the treatment efficacy of drugs and reduce their side effects. HIGHLIGHTS: Polymersomes encapsulate both hydrophilic/hydrophobic drugs for synergy. Progress in their preparation, loading, and functionalization is summarized. Key applications in tumor therapy, gene editing, and anti-infection are highlighted. [ABSTRACT FROM AUTHOR]
ISSN:10601325
DOI:10.1080/10601325.2026.2634114