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Advancements of polymersomes in drug delivery systems.

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Title: Advancements of polymersomes in drug delivery systems.
Authors: Yang, Zhuang1 (AUTHOR), Xiong, Xiang Yuan1 (AUTHOR) xy.xiong@qq.com
Source: Journal of Macromolecular Science: Pure & Applied Chemistry. 2026, Vol. 63 Issue 5, p375-395. 21p.
Subjects: Polymersomes, Drug delivery systems, Targeted drug delivery, Pharmaceutical encapsulation, Block copolymers, Nanomedicine, Genome editing, Infection prevention
Abstract: Polymersomes, self-assembled from amphiphilic block copolymers, are nanoscale vesicles with a hydrophilic core and a hydrophobic bilayer. This unique structure allows them to efficiently encapsulate both hydrophilic and hydrophobic drugs, enabling co-delivery and synergistic therapeutic effects. This review systematically summarized their preparation methods, drug loading strategies, and functionalization approaches, highlighting recent applications in tumor-targeted therapy, gene editing, and anti-infection treatment. Despite ongoing challenges in scalable production, quality control, and clinical translation, polymersomes represent a promising intelligent platform for nano drug delivery with significant potential to enhance the treatment efficacy of drugs and reduce their side effects. HIGHLIGHTS: Polymersomes encapsulate both hydrophilic/hydrophobic drugs for synergy. Progress in their preparation, loading, and functionalization is summarized. Key applications in tumor therapy, gene editing, and anti-infection are highlighted. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Macromolecular Science: Pure & Applied Chemistry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 193318332
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Advancements of polymersomes in drug delivery systems.
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  Data: <searchLink fieldCode="AR" term="%22Yang%2C+Zhuang%22">Yang, Zhuang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xiong%2C+Xiang+Yuan%22">Xiong, Xiang Yuan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> xy.xiong@qq.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Macromolecular+Science%3A+Pure+%26+Applied+Chemistry%22">Journal of Macromolecular Science: Pure & Applied Chemistry</searchLink>. 2026, Vol. 63 Issue 5, p375-395. 21p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Polymersomes%22">Polymersomes</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+delivery+systems%22">Drug delivery systems</searchLink><br /><searchLink fieldCode="DE" term="%22Targeted+drug+delivery%22">Targeted drug delivery</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmaceutical+encapsulation%22">Pharmaceutical encapsulation</searchLink><br /><searchLink fieldCode="DE" term="%22Block+copolymers%22">Block copolymers</searchLink><br /><searchLink fieldCode="DE" term="%22Nanomedicine%22">Nanomedicine</searchLink><br /><searchLink fieldCode="DE" term="%22Genome+editing%22">Genome editing</searchLink><br /><searchLink fieldCode="DE" term="%22Infection+prevention%22">Infection prevention</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Polymersomes, self-assembled from amphiphilic block copolymers, are nanoscale vesicles with a hydrophilic core and a hydrophobic bilayer. This unique structure allows them to efficiently encapsulate both hydrophilic and hydrophobic drugs, enabling co-delivery and synergistic therapeutic effects. This review systematically summarized their preparation methods, drug loading strategies, and functionalization approaches, highlighting recent applications in tumor-targeted therapy, gene editing, and anti-infection treatment. Despite ongoing challenges in scalable production, quality control, and clinical translation, polymersomes represent a promising intelligent platform for nano drug delivery with significant potential to enhance the treatment efficacy of drugs and reduce their side effects. HIGHLIGHTS: Polymersomes encapsulate both hydrophilic/hydrophobic drugs for synergy. Progress in their preparation, loading, and functionalization is summarized. Key applications in tumor therapy, gene editing, and anti-infection are highlighted. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Macromolecular Science: Pure & Applied Chemistry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=193318332
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/10601325.2026.2634114
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      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 21
        StartPage: 375
    Subjects:
      – SubjectFull: Polymersomes
        Type: general
      – SubjectFull: Drug delivery systems
        Type: general
      – SubjectFull: Targeted drug delivery
        Type: general
      – SubjectFull: Pharmaceutical encapsulation
        Type: general
      – SubjectFull: Block copolymers
        Type: general
      – SubjectFull: Nanomedicine
        Type: general
      – SubjectFull: Genome editing
        Type: general
      – SubjectFull: Infection prevention
        Type: general
    Titles:
      – TitleFull: Advancements of polymersomes in drug delivery systems.
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            NameFull: Yang, Zhuang
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          Name:
            NameFull: Xiong, Xiang Yuan
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          Dates:
            – D: 01
              M: 05
              Text: 2026
              Type: published
              Y: 2026
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              Value: 63
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              Value: 5
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            – TitleFull: Journal of Macromolecular Science: Pure & Applied Chemistry
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