Biodegradable Metals and Corrosion Control: Challenges, Limits and New Opportunities for Innovating in Orthopedic Fixations.
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| Title: | Biodegradable Metals and Corrosion Control: Challenges, Limits and New Opportunities for Innovating in Orthopedic Fixations. |
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| Authors: | Cherqaoui, Abdelhakim1 (AUTHOR), Paternoster, Carlo1 (AUTHOR), Mantovani, Diego1 (AUTHOR) diego.mantovani@gmn.ulaval.ca |
| Source: | Materials (1996-1944). May2026, Vol. 19 Issue 9, p1789. 36p. |
| Subjects: | Iron-manganese alloys, Biodegradable materials, Osseointegration, Orthopedic surgery, Chemical decomposition, Biomechanics, Corrosion control industry, Solid freeform fabrication |
| Abstract: | Biodegradable metals represent a paradigm shift in orthopedic fixation by providing temporary mechanical support synchronized with bone healing while eliminating long-term complications associated with permanent implants. Conventional bioinert alloys, including stainless steels, Ti-based alloys, and Co-Cr alloys, exhibit high elastic moduli that induce stress shielding and often require secondary removal surgeries. In response, resorbable metallic systems based on Mg, Zn, and Fe have emerged as promising alternatives. Among these, Fe-Mn-C alloys stand out for load-bearing applications due to their exceptional strength-ductility balance governed by twinning-induced plasticity mechanisms, tunable degradation behavior, and intrinsic magnetic resonance imaging compatibility through austenitic phase stabilization. Focusing on Fe-Mn-C alloys, this review critically examines the metallurgical design principles underlying stacking fault energy optimization, phase stability, and Mn-controlled electrochemical behavior. Processing innovations, such as additive manufacturing, are discussed as tools to architecture porosity, refine microstructure, and accelerate degradation by graded designs while preserving mechanical structural support during healing. Hybrid metallic-bioactive systems, surface functionalization strategies, and functionally graded porous architectures were evaluated as advanced approaches to enhance osteointegration and modulate degradability. Despite these advances, significant barriers remain for clinical translation. Persistent discrepancies between in vitro and in vivo degradation rates, often attributed to biological encapsulation and degradation product accumulation, complicate lifetime prediction. Localized corrosion at microstructural heterogeneities such as twin boundaries and phase interfaces can undermine structural reliability under load-bearing conditions. Moreover, predictive multi-physics modeling frameworks capable of coupling electrochemical kinetics, mechanical loading, microstructural evolution, and bone remodeling remain underdeveloped, limiting reliable safety-margin estimation. Regulatory progress is further hindered by the absence of standardized testing protocols specifically tailored to Fe-based biodegradable alloys, including harmonized degradation rate windows, validated corrosion-mechanics coupling methodologies, and clinically defined Mn ion release thresholds. This review aims to discuss whether Fe-based alloys, especially Fe-Mn-C alloys, can transition from promising laboratory materials to clinically viable next-generation orthopedic implants capable of delivering patient-specific, mechanically compatible, and biologically synchronized temporary fixation. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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| Abstract: | Biodegradable metals represent a paradigm shift in orthopedic fixation by providing temporary mechanical support synchronized with bone healing while eliminating long-term complications associated with permanent implants. Conventional bioinert alloys, including stainless steels, Ti-based alloys, and Co-Cr alloys, exhibit high elastic moduli that induce stress shielding and often require secondary removal surgeries. In response, resorbable metallic systems based on Mg, Zn, and Fe have emerged as promising alternatives. Among these, Fe-Mn-C alloys stand out for load-bearing applications due to their exceptional strength-ductility balance governed by twinning-induced plasticity mechanisms, tunable degradation behavior, and intrinsic magnetic resonance imaging compatibility through austenitic phase stabilization. Focusing on Fe-Mn-C alloys, this review critically examines the metallurgical design principles underlying stacking fault energy optimization, phase stability, and Mn-controlled electrochemical behavior. Processing innovations, such as additive manufacturing, are discussed as tools to architecture porosity, refine microstructure, and accelerate degradation by graded designs while preserving mechanical structural support during healing. Hybrid metallic-bioactive systems, surface functionalization strategies, and functionally graded porous architectures were evaluated as advanced approaches to enhance osteointegration and modulate degradability. Despite these advances, significant barriers remain for clinical translation. Persistent discrepancies between in vitro and in vivo degradation rates, often attributed to biological encapsulation and degradation product accumulation, complicate lifetime prediction. Localized corrosion at microstructural heterogeneities such as twin boundaries and phase interfaces can undermine structural reliability under load-bearing conditions. Moreover, predictive multi-physics modeling frameworks capable of coupling electrochemical kinetics, mechanical loading, microstructural evolution, and bone remodeling remain underdeveloped, limiting reliable safety-margin estimation. Regulatory progress is further hindered by the absence of standardized testing protocols specifically tailored to Fe-based biodegradable alloys, including harmonized degradation rate windows, validated corrosion-mechanics coupling methodologies, and clinically defined Mn ion release thresholds. This review aims to discuss whether Fe-based alloys, especially Fe-Mn-C alloys, can transition from promising laboratory materials to clinically viable next-generation orthopedic implants capable of delivering patient-specific, mechanically compatible, and biologically synchronized temporary fixation. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 19961944 |
| DOI: | 10.3390/ma19091789 |
