3D-Printed Polylactide-Based Implants: Influence of Processing, Radiation Sterilization and In Vivo Bioresorption on Structural and Physicochemical Material Characteristics.
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| Title: | 3D-Printed Polylactide-Based Implants: Influence of Processing, Radiation Sterilization and In Vivo Bioresorption on Structural and Physicochemical Material Characteristics. |
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| Authors: | Dobrzyńska-Mizera, Monika1 (AUTHOR) monika.dobrzynska-mizera@put.poznan.pl, Knitter, Monika1,2 (AUTHOR), Muzalewska, Małgorzata2,3 (AUTHOR), Wyleżoł, Marek2,4 (AUTHOR), Andrzejewski, Jacek1,5 (AUTHOR), Mietliński, Patryk3,6 (AUTHOR), Gapiński, Bartosz1,3 (AUTHOR), Stagraczyński, Maciej2,4 (AUTHOR), Mikulski, Michał3,5 (AUTHOR), Longo, Alessandra4,6 (AUTHOR), Dal Poggetto, Giovanni5,6 (AUTHOR), Barone, Maria Cristina Del6 (AUTHOR), Di Lorenzo, Maria Laura6 (AUTHOR) |
| Source: | Polymers (20734360). May2026, Vol. 18 Issue 9, p1034. 23p. |
| Subjects: | Radiation sterilization, Bioabsorbable implants, Hydroxyapatite, Bone regeneration, Three-dimensional printing, Biodegradation, Polymer degradation, Tissue engineering |
| Abstract: | The manuscript details the influence of high-temperature and high-shear processing, as well as radiation sterilization, on properties of bioresorbable and osteoconductive, patient-tailored alloplastic scaffolds for guided bone regeneration. Functionalized poly(l-lactide-co-d,l-lactide) copolymer filled with hydroxyapatite was used to produce two personalized implants for upper and lower jaw reconstruction via 3D printing. Morphology analysis (SEM, µCT), gel permeation chromatography, and thermal analysis quantified the effects of melt processing and sterilization on chain structure. Physical properties of sterilized parts, such as hardness and density, proved suitable for bone implants. Removal of the upper jaw implant after 4 months and of the lower jaw substitute after 18 months enabled monitoring of bioresorption and tissue regrowth over time. Gradual overgrowth of the implants with human tissue, initiated by the osteoconductive filler, was observed, along with time-dependent polylactide degradation, showing up to 92% molar mass reduction. The medical procedures confirmed safety, nontoxicity, non-allergenicity, and, most importantly, the tissue-forming properties of the polylactide-based formulation. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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