Mechanical properties of bone cells studied by atomic force microscopy.
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| Title: | Mechanical properties of bone cells studied by atomic force microscopy. |
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| Authors: | Zhang, Xiaoqi1,2,3 (AUTHOR), Wang, Zuobin1,2,3,4 (AUTHOR) wangz@cust.edu.cn, Yu, Haiyue1,2,3 (AUTHOR), Tao, Zengren1,2,3 (AUTHOR), Ji, Wei1,2,3,5 (AUTHOR) jiweism@cust.edu.cn |
| Source: | Journal of Microscopy. May2026, Vol. 302 Issue 2, p147-159. 13p. |
| Subjects: | Osteoblasts, Atomic force microscopy, Bone cells, Bone diseases, Extracellular matrix, Mechanical behavior of materials, Cell imaging, Bone growth |
| Abstract: | Osteoblasts are the functional cells capable of bone formation in the bone microenvironment and play an important role in bone growth, development, and the maintenance of bone mass. The cells cultured in vitro are derived from preosteoblasts in tissues and possess the ability to divide and proliferate. Osteoblasts form the bone matrix by secreting collagen and other matrix proteins, which provides a foundation for the deposition of minerals such as calcium and phosphorus, ultimately resulting in the formation of hard bone tissue. Bone diseases affect the quality of life and the aging of the population. Bone diseases such as osteoporosis, fractures, bone tumours, and arthritis have a significant impact on quality of life, especially among the elderly population. These realities remind us that we should pay more attention to bone and joint health. Therefore, it is particularly important to study the imaging and characterisation of mechanical properties of bone cells, which provides a basis for the research of bone diseases in human beings. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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| Abstract: | Osteoblasts are the functional cells capable of bone formation in the bone microenvironment and play an important role in bone growth, development, and the maintenance of bone mass. The cells cultured in vitro are derived from preosteoblasts in tissues and possess the ability to divide and proliferate. Osteoblasts form the bone matrix by secreting collagen and other matrix proteins, which provides a foundation for the deposition of minerals such as calcium and phosphorus, ultimately resulting in the formation of hard bone tissue. Bone diseases affect the quality of life and the aging of the population. Bone diseases such as osteoporosis, fractures, bone tumours, and arthritis have a significant impact on quality of life, especially among the elderly population. These realities remind us that we should pay more attention to bone and joint health. Therefore, it is particularly important to study the imaging and characterisation of mechanical properties of bone cells, which provides a basis for the research of bone diseases in human beings. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 00222720 |
| DOI: | 10.1111/jmi.13373 |
