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Mechanical properties of bone cells studied by atomic force microscopy.

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Title: Mechanical properties of bone cells studied by atomic force microscopy.
Authors: Zhang, Xiaoqi1,2,3 (AUTHOR), Wang, Zuobin1,2,3,4 (AUTHOR) wangz@cust.edu.cn, Yu, Haiyue1,2,3 (AUTHOR), Tao, Zengren1,2,3 (AUTHOR), Ji, Wei1,2,3,5 (AUTHOR) jiweism@cust.edu.cn
Source: Journal of Microscopy. May2026, Vol. 302 Issue 2, p147-159. 13p.
Subjects: Osteoblasts, Atomic force microscopy, Bone cells, Bone diseases, Extracellular matrix, Mechanical behavior of materials, Cell imaging, Bone growth
Abstract: Osteoblasts are the functional cells capable of bone formation in the bone microenvironment and play an important role in bone growth, development, and the maintenance of bone mass. The cells cultured in vitro are derived from preosteoblasts in tissues and possess the ability to divide and proliferate. Osteoblasts form the bone matrix by secreting collagen and other matrix proteins, which provides a foundation for the deposition of minerals such as calcium and phosphorus, ultimately resulting in the formation of hard bone tissue. Bone diseases affect the quality of life and the aging of the population. Bone diseases such as osteoporosis, fractures, bone tumours, and arthritis have a significant impact on quality of life, especially among the elderly population. These realities remind us that we should pay more attention to bone and joint health. Therefore, it is particularly important to study the imaging and characterisation of mechanical properties of bone cells, which provides a basis for the research of bone diseases in human beings. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Microscopy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Mechanical properties of bone cells studied by atomic force microscopy.
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  Data: <searchLink fieldCode="AR" term="%22Zhang%2C+Xiaoqi%22">Zhang, Xiaoqi</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Zuobin%22">Wang, Zuobin</searchLink><relatesTo>1,2,3,4</relatesTo> (AUTHOR)<i> wangz@cust.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Yu%2C+Haiyue%22">Yu, Haiyue</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tao%2C+Zengren%22">Tao, Zengren</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ji%2C+Wei%22">Ji, Wei</searchLink><relatesTo>1,2,3,5</relatesTo> (AUTHOR)<i> jiweism@cust.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Microscopy%22">Journal of Microscopy</searchLink>. May2026, Vol. 302 Issue 2, p147-159. 13p.
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  Data: <searchLink fieldCode="DE" term="%22Osteoblasts%22">Osteoblasts</searchLink><br /><searchLink fieldCode="DE" term="%22Atomic+force+microscopy%22">Atomic force microscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+cells%22">Bone cells</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+diseases%22">Bone diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Extracellular+matrix%22">Extracellular matrix</searchLink><br /><searchLink fieldCode="DE" term="%22Mechanical+behavior+of+materials%22">Mechanical behavior of materials</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+imaging%22">Cell imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+growth%22">Bone growth</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Osteoblasts are the functional cells capable of bone formation in the bone microenvironment and play an important role in bone growth, development, and the maintenance of bone mass. The cells cultured in vitro are derived from preosteoblasts in tissues and possess the ability to divide and proliferate. Osteoblasts form the bone matrix by secreting collagen and other matrix proteins, which provides a foundation for the deposition of minerals such as calcium and phosphorus, ultimately resulting in the formation of hard bone tissue. Bone diseases affect the quality of life and the aging of the population. Bone diseases such as osteoporosis, fractures, bone tumours, and arthritis have a significant impact on quality of life, especially among the elderly population. These realities remind us that we should pay more attention to bone and joint health. Therefore, it is particularly important to study the imaging and characterisation of mechanical properties of bone cells, which provides a basis for the research of bone diseases in human beings. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Microscopy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1111/jmi.13373
    Languages:
      – Code: eng
        Text: English
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      Pagination:
        PageCount: 13
        StartPage: 147
    Subjects:
      – SubjectFull: Osteoblasts
        Type: general
      – SubjectFull: Atomic force microscopy
        Type: general
      – SubjectFull: Bone cells
        Type: general
      – SubjectFull: Bone diseases
        Type: general
      – SubjectFull: Extracellular matrix
        Type: general
      – SubjectFull: Mechanical behavior of materials
        Type: general
      – SubjectFull: Cell imaging
        Type: general
      – SubjectFull: Bone growth
        Type: general
    Titles:
      – TitleFull: Mechanical properties of bone cells studied by atomic force microscopy.
        Type: main
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      – PersonEntity:
          Name:
            NameFull: Zhang, Xiaoqi
      – PersonEntity:
          Name:
            NameFull: Wang, Zuobin
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            NameFull: Yu, Haiyue
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            NameFull: Tao, Zengren
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            NameFull: Ji, Wei
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          Dates:
            – D: 01
              M: 05
              Text: May2026
              Type: published
              Y: 2026
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              Value: 302
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