A novel nerve guide conduit applied with conductive polymer PEDOT: PSS for repair of long sciatic nerve gap.
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| Title: | A novel nerve guide conduit applied with conductive polymer PEDOT: PSS for repair of long sciatic nerve gap. |
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| Authors: | Xiao, Duanqiang1,2 (AUTHOR), Pan, Xueyu1,2 (AUTHOR), Jiao, Enxiang1,3 (AUTHOR), Yuan, Kunshan2 (AUTHOR), Li, Kun1,3 (AUTHOR), Li, Yuechuan4 (AUTHOR), Deng, Chengchen2 (AUTHOR), Tang, Hui2,3 (AUTHOR), Sun, Ziru2 (AUTHOR), Ren, Guiying5 (AUTHOR), Xu, Meihong1,2 (AUTHOR), Cheng, Xiangfeng6 (AUTHOR), Guo, Kai1,3 (AUTHOR) kaiguo@sdut.edu.cn, Liu, Yuanbiao1,3 (AUTHOR) ybliu@sdut.edu.cn, Zhang, Haijun1,2,3 (AUTHOR) zhanghaijun@tongji.edu.cn |
| Source: | Polymers & Polymer Composites. 5/25/2026, Vol. 34, p1-17. 17p. |
| Subjects: | Conducting polymer composites, Polycaprolactone, Nervous system regeneration, Peripheral nerve injuries, Schwann cells, Electric stimulation, Conducting polymers, Sciatic nerve injuries |
| Abstract: | Despite that artificial nerve guide conduits (NGC) have been widely applied in nerve tissue repair for treating peripheral nerve injury (PNI), those apparatuses face great challenges in repairing long-gap nerve defects due to their non-conductive nature. Herein, we report that such clinical issue can be addressed by a bio-mimic polycaprolactone (PCL)-based nerve conduit doped with conductive mixtures (denoted as PP) of polyethylene dioxythiophene (PEDOT) and polystyrene sulfonate (PSS). The PCL-PP nerve conduits demonstrated porous reticular fibrous networks with biocompatible and physicochemical properties. The structure novelty endows the material with a robust mechanical character with a Young's modulus of 0.32 MPa and a tensile strength of 2.9 MPa. Benefited from the capability of conducting endogenous electrical stimulation due to the high conductivity of 5.8 × 10-3 S/m, the PCL-PP nerve conduits can regulate the biological behavior of Schwann cells (SCs), and remarkably promote the myelin sheath growth and regeneration of nerve tissues in a 10 mm sciatic nerve defect SD rat model. Compared to the contrast nerve conduits without PP compositions, the PCL-PP nerve conduits accelerated the recovery rate of extremity motor function of SD rats by a factor of 1.25-fold. These findings prove that our reported novel PCL-PP composite nerve conduit with functional integration of bioelectrical stimulation is a promising therapeutic approach toward PNI therapy. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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| Abstract: | Despite that artificial nerve guide conduits (NGC) have been widely applied in nerve tissue repair for treating peripheral nerve injury (PNI), those apparatuses face great challenges in repairing long-gap nerve defects due to their non-conductive nature. Herein, we report that such clinical issue can be addressed by a bio-mimic polycaprolactone (PCL)-based nerve conduit doped with conductive mixtures (denoted as PP) of polyethylene dioxythiophene (PEDOT) and polystyrene sulfonate (PSS). The PCL-PP nerve conduits demonstrated porous reticular fibrous networks with biocompatible and physicochemical properties. The structure novelty endows the material with a robust mechanical character with a Young's modulus of 0.32 MPa and a tensile strength of 2.9 MPa. Benefited from the capability of conducting endogenous electrical stimulation due to the high conductivity of 5.8 × 10-3 S/m, the PCL-PP nerve conduits can regulate the biological behavior of Schwann cells (SCs), and remarkably promote the myelin sheath growth and regeneration of nerve tissues in a 10 mm sciatic nerve defect SD rat model. Compared to the contrast nerve conduits without PP compositions, the PCL-PP nerve conduits accelerated the recovery rate of extremity motor function of SD rats by a factor of 1.25-fold. These findings prove that our reported novel PCL-PP composite nerve conduit with functional integration of bioelectrical stimulation is a promising therapeutic approach toward PNI therapy. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 09673911 |
| DOI: | 10.1177/09673911261454110 |
