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A novel nerve guide conduit applied with conductive polymer PEDOT: PSS for repair of long sciatic nerve gap.

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Title: A novel nerve guide conduit applied with conductive polymer PEDOT: PSS for repair of long sciatic nerve gap.
Authors: Xiao, Duanqiang1,2 (AUTHOR), Pan, Xueyu1,2 (AUTHOR), Jiao, Enxiang1,3 (AUTHOR), Yuan, Kunshan2 (AUTHOR), Li, Kun1,3 (AUTHOR), Li, Yuechuan4 (AUTHOR), Deng, Chengchen2 (AUTHOR), Tang, Hui2,3 (AUTHOR), Sun, Ziru2 (AUTHOR), Ren, Guiying5 (AUTHOR), Xu, Meihong1,2 (AUTHOR), Cheng, Xiangfeng6 (AUTHOR), Guo, Kai1,3 (AUTHOR) kaiguo@sdut.edu.cn, Liu, Yuanbiao1,3 (AUTHOR) ybliu@sdut.edu.cn, Zhang, Haijun1,2,3 (AUTHOR) zhanghaijun@tongji.edu.cn
Source: Polymers & Polymer Composites. 5/25/2026, Vol. 34, p1-17. 17p.
Subjects: Conducting polymer composites, Polycaprolactone, Nervous system regeneration, Peripheral nerve injuries, Schwann cells, Electric stimulation, Conducting polymers, Sciatic nerve injuries
Abstract: Despite that artificial nerve guide conduits (NGC) have been widely applied in nerve tissue repair for treating peripheral nerve injury (PNI), those apparatuses face great challenges in repairing long-gap nerve defects due to their non-conductive nature. Herein, we report that such clinical issue can be addressed by a bio-mimic polycaprolactone (PCL)-based nerve conduit doped with conductive mixtures (denoted as PP) of polyethylene dioxythiophene (PEDOT) and polystyrene sulfonate (PSS). The PCL-PP nerve conduits demonstrated porous reticular fibrous networks with biocompatible and physicochemical properties. The structure novelty endows the material with a robust mechanical character with a Young's modulus of 0.32 MPa and a tensile strength of 2.9 MPa. Benefited from the capability of conducting endogenous electrical stimulation due to the high conductivity of 5.8 × 10-3 S/m, the PCL-PP nerve conduits can regulate the biological behavior of Schwann cells (SCs), and remarkably promote the myelin sheath growth and regeneration of nerve tissues in a 10 mm sciatic nerve defect SD rat model. Compared to the contrast nerve conduits without PP compositions, the PCL-PP nerve conduits accelerated the recovery rate of extremity motor function of SD rats by a factor of 1.25-fold. These findings prove that our reported novel PCL-PP composite nerve conduit with functional integration of bioelectrical stimulation is a promising therapeutic approach toward PNI therapy. [ABSTRACT FROM AUTHOR]
Copyright of Polymers & Polymer Composites is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
  Group: Ti
  Data: A novel nerve guide conduit applied with conductive polymer PEDOT: PSS for repair of long sciatic nerve gap.
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  Data: <searchLink fieldCode="AR" term="%22Xiao%2C+Duanqiang%22">Xiao, Duanqiang</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pan%2C+Xueyu%22">Pan, Xueyu</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jiao%2C+Enxiang%22">Jiao, Enxiang</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yuan%2C+Kunshan%22">Yuan, Kunshan</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Kun%22">Li, Kun</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Yuechuan%22">Li, Yuechuan</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Deng%2C+Chengchen%22">Deng, Chengchen</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tang%2C+Hui%22">Tang, Hui</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sun%2C+Ziru%22">Sun, Ziru</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ren%2C+Guiying%22">Ren, Guiying</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Meihong%22">Xu, Meihong</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cheng%2C+Xiangfeng%22">Cheng, Xiangfeng</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guo%2C+Kai%22">Guo, Kai</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> kaiguo@sdut.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Liu%2C+Yuanbiao%22">Liu, Yuanbiao</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> ybliu@sdut.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Haijun%22">Zhang, Haijun</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<i> zhanghaijun@tongji.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Polymers+%26+Polymer+Composites%22">Polymers & Polymer Composites</searchLink>. 5/25/2026, Vol. 34, p1-17. 17p.
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  Data: <searchLink fieldCode="DE" term="%22Conducting+polymer+composites%22">Conducting polymer composites</searchLink><br /><searchLink fieldCode="DE" term="%22Polycaprolactone%22">Polycaprolactone</searchLink><br /><searchLink fieldCode="DE" term="%22Nervous+system+regeneration%22">Nervous system regeneration</searchLink><br /><searchLink fieldCode="DE" term="%22Peripheral+nerve+injuries%22">Peripheral nerve injuries</searchLink><br /><searchLink fieldCode="DE" term="%22Schwann+cells%22">Schwann cells</searchLink><br /><searchLink fieldCode="DE" term="%22Electric+stimulation%22">Electric stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Conducting+polymers%22">Conducting polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Sciatic+nerve+injuries%22">Sciatic nerve injuries</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Despite that artificial nerve guide conduits (NGC) have been widely applied in nerve tissue repair for treating peripheral nerve injury (PNI), those apparatuses face great challenges in repairing long-gap nerve defects due to their non-conductive nature. Herein, we report that such clinical issue can be addressed by a bio-mimic polycaprolactone (PCL)-based nerve conduit doped with conductive mixtures (denoted as PP) of polyethylene dioxythiophene (PEDOT) and polystyrene sulfonate (PSS). The PCL-PP nerve conduits demonstrated porous reticular fibrous networks with biocompatible and physicochemical properties. The structure novelty endows the material with a robust mechanical character with a Young's modulus of 0.32 MPa and a tensile strength of 2.9 MPa. Benefited from the capability of conducting endogenous electrical stimulation due to the high conductivity of 5.8 × 10-3 S/m, the PCL-PP nerve conduits can regulate the biological behavior of Schwann cells (SCs), and remarkably promote the myelin sheath growth and regeneration of nerve tissues in a 10 mm sciatic nerve defect SD rat model. Compared to the contrast nerve conduits without PP compositions, the PCL-PP nerve conduits accelerated the recovery rate of extremity motor function of SD rats by a factor of 1.25-fold. These findings prove that our reported novel PCL-PP composite nerve conduit with functional integration of bioelectrical stimulation is a promising therapeutic approach toward PNI therapy. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Polymers & Polymer Composites is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1177/09673911261454110
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 17
        StartPage: 1
    Subjects:
      – SubjectFull: Conducting polymer composites
        Type: general
      – SubjectFull: Polycaprolactone
        Type: general
      – SubjectFull: Nervous system regeneration
        Type: general
      – SubjectFull: Peripheral nerve injuries
        Type: general
      – SubjectFull: Schwann cells
        Type: general
      – SubjectFull: Electric stimulation
        Type: general
      – SubjectFull: Conducting polymers
        Type: general
      – SubjectFull: Sciatic nerve injuries
        Type: general
    Titles:
      – TitleFull: A novel nerve guide conduit applied with conductive polymer PEDOT: PSS for repair of long sciatic nerve gap.
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              Text: 5/25/2026
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              Y: 2026
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