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Development of biocompatible MOF-impregnated PVA films with broad-spectrum antimicrobial surface properties by efficient in-situ method.

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Title: Development of biocompatible MOF-impregnated PVA films with broad-spectrum antimicrobial surface properties by efficient in-situ method.
Authors: Timin, Alexander S.1 (AUTHOR) a_timin@mail.ru, Pochkaeva, Evgeniia I.1,2 (AUTHOR), Nosova, Natalya A.1 (AUTHOR), Sergeeva, Radmila R.1 (AUTHOR), Brodskaya, Aleksandra V.3 (AUTHOR), Ivanchenko, Olga B.2 (AUTHOR), Nur, Sheila A.3 (AUTHOR), Rogova, Anna1 (AUTHOR), Lipin, Dmitry V.4 (AUTHOR), Ganin, Sergei V.5 (AUTHOR), Ivanova, Galina V.6 (AUTHOR), Shipilovskikh, Sergei A.1,4 (AUTHOR) s.shipilovskikh@mail.ru
Source: Applied Surface Science. Oct2026, Vol. 743, pN.PAG-N.PAG. 1p.
Subjects: Polyvinyl alcohol, Metal-organic frameworks, Antibacterial agents, Biocompatibility, Antifungal agents, Biomedical materials, Biological interfaces
Abstract: [Display omitted] • PVA-based hybrid films incorporated with MOFs were developed by one-pot efficient method. • SEM and optical microscopy revealed morphological changes after MOFs incorporation. • It was determined the influence of incorporated MOFs on mechanical and surface properties of hybrid films. • The hybrid films exhibited excellent antibacterial and antifungal activities compared to individual MOFs. • The hybrid films demonstrated high biocompatibility towards animal model. We design hybrid films made of polyvinyl alcohol (PVA) and HKUST-1 synthesized with efficient in-situ method. It was clearly confirmed in-situ incorporation of HKUST-1 crystals into PVA matrix. It was determined that various percentages of incorporated HKUST-1 (w/v% = 0.1, 0.5, 1 and 2%) have strong influence on surface properties of the developed PVA/HKUST-1 hybrid films. The developed PVA/HKUST-1 (w/v% = 0.1, 0.5, 1 and 2%) hybrid films demonstrated dose-dependent in vitro toxicity. These PVA/HKUST-1 films exhibit excellent antibacterial (Pseudomonas, Escherichia coli, Bacillus subtilis, Serratia marcescens, Klebsiella and Micrococcus) and antifungal activities (Saccharomyces cerevisiae , Rodotorulla rubra and Saccharomyces boulardii). At the same time, no significant side effects were detected, i.e. skin irritation test, blood biochemical analysis and histological analysis of skin tissues did not reveal any pathological factors. In addition, the histological analysis of the main organs (lungs, heart, liver, kidney, and spleen) did not detect any morphological changes of tissues after deposition of PVA/HKUST-1 films onto mouse skin. Finally, all estimated characteristics of efficient and in-situ synthesized PVA/HKUST-1 films are in favor of recommending these materials for preclinical studies. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
Description
Abstract:[Display omitted] • PVA-based hybrid films incorporated with MOFs were developed by one-pot efficient method. • SEM and optical microscopy revealed morphological changes after MOFs incorporation. • It was determined the influence of incorporated MOFs on mechanical and surface properties of hybrid films. • The hybrid films exhibited excellent antibacterial and antifungal activities compared to individual MOFs. • The hybrid films demonstrated high biocompatibility towards animal model. We design hybrid films made of polyvinyl alcohol (PVA) and HKUST-1 synthesized with efficient in-situ method. It was clearly confirmed in-situ incorporation of HKUST-1 crystals into PVA matrix. It was determined that various percentages of incorporated HKUST-1 (w/v% = 0.1, 0.5, 1 and 2%) have strong influence on surface properties of the developed PVA/HKUST-1 hybrid films. The developed PVA/HKUST-1 (w/v% = 0.1, 0.5, 1 and 2%) hybrid films demonstrated dose-dependent in vitro toxicity. These PVA/HKUST-1 films exhibit excellent antibacterial (Pseudomonas, Escherichia coli, Bacillus subtilis, Serratia marcescens, Klebsiella and Micrococcus) and antifungal activities (Saccharomyces cerevisiae , Rodotorulla rubra and Saccharomyces boulardii). At the same time, no significant side effects were detected, i.e. skin irritation test, blood biochemical analysis and histological analysis of skin tissues did not reveal any pathological factors. In addition, the histological analysis of the main organs (lungs, heart, liver, kidney, and spleen) did not detect any morphological changes of tissues after deposition of PVA/HKUST-1 films onto mouse skin. Finally, all estimated characteristics of efficient and in-situ synthesized PVA/HKUST-1 films are in favor of recommending these materials for preclinical studies. [ABSTRACT FROM AUTHOR]
ISSN:01694332
DOI:10.1016/j.apsusc.2026.167301