View in EDS

Development of biocompatible MOF-impregnated PVA films with broad-spectrum antimicrobial surface properties by efficient in-situ method.

Saved in:
Bibliographic Details
Title: Development of biocompatible MOF-impregnated PVA films with broad-spectrum antimicrobial surface properties by efficient in-situ method.
Authors: Timin, Alexander S.1 (AUTHOR) a_timin@mail.ru, Pochkaeva, Evgeniia I.1,2 (AUTHOR), Nosova, Natalya A.1 (AUTHOR), Sergeeva, Radmila R.1 (AUTHOR), Brodskaya, Aleksandra V.3 (AUTHOR), Ivanchenko, Olga B.2 (AUTHOR), Nur, Sheila A.3 (AUTHOR), Rogova, Anna1 (AUTHOR), Lipin, Dmitry V.4 (AUTHOR), Ganin, Sergei V.5 (AUTHOR), Ivanova, Galina V.6 (AUTHOR), Shipilovskikh, Sergei A.1,4 (AUTHOR) s.shipilovskikh@mail.ru
Source: Applied Surface Science. Oct2026, Vol. 743, pN.PAG-N.PAG. 1p.
Subjects: Polyvinyl alcohol, Metal-organic frameworks, Antibacterial agents, Biocompatibility, Antifungal agents, Biomedical materials, Biological interfaces
Abstract: [Display omitted] • PVA-based hybrid films incorporated with MOFs were developed by one-pot efficient method. • SEM and optical microscopy revealed morphological changes after MOFs incorporation. • It was determined the influence of incorporated MOFs on mechanical and surface properties of hybrid films. • The hybrid films exhibited excellent antibacterial and antifungal activities compared to individual MOFs. • The hybrid films demonstrated high biocompatibility towards animal model. We design hybrid films made of polyvinyl alcohol (PVA) and HKUST-1 synthesized with efficient in-situ method. It was clearly confirmed in-situ incorporation of HKUST-1 crystals into PVA matrix. It was determined that various percentages of incorporated HKUST-1 (w/v% = 0.1, 0.5, 1 and 2%) have strong influence on surface properties of the developed PVA/HKUST-1 hybrid films. The developed PVA/HKUST-1 (w/v% = 0.1, 0.5, 1 and 2%) hybrid films demonstrated dose-dependent in vitro toxicity. These PVA/HKUST-1 films exhibit excellent antibacterial (Pseudomonas, Escherichia coli, Bacillus subtilis, Serratia marcescens, Klebsiella and Micrococcus) and antifungal activities (Saccharomyces cerevisiae , Rodotorulla rubra and Saccharomyces boulardii). At the same time, no significant side effects were detected, i.e. skin irritation test, blood biochemical analysis and histological analysis of skin tissues did not reveal any pathological factors. In addition, the histological analysis of the main organs (lungs, heart, liver, kidney, and spleen) did not detect any morphological changes of tissues after deposition of PVA/HKUST-1 films onto mouse skin. Finally, all estimated characteristics of efficient and in-situ synthesized PVA/HKUST-1 films are in favor of recommending these materials for preclinical studies. [ABSTRACT FROM AUTHOR]
Copyright of Applied Surface Science is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 194294497
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Development of biocompatible MOF-impregnated PVA films with broad-spectrum antimicrobial surface properties by efficient in-situ method.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Timin%2C+Alexander+S%2E%22">Timin, Alexander S.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> a_timin@mail.ru</i><br /><searchLink fieldCode="AR" term="%22Pochkaeva%2C+Evgeniia+I%2E%22">Pochkaeva, Evgeniia I.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nosova%2C+Natalya+A%2E%22">Nosova, Natalya A.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sergeeva%2C+Radmila+R%2E%22">Sergeeva, Radmila R.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Brodskaya%2C+Aleksandra+V%2E%22">Brodskaya, Aleksandra V.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ivanchenko%2C+Olga+B%2E%22">Ivanchenko, Olga B.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nur%2C+Sheila+A%2E%22">Nur, Sheila A.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rogova%2C+Anna%22">Rogova, Anna</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lipin%2C+Dmitry+V%2E%22">Lipin, Dmitry V.</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ganin%2C+Sergei+V%2E%22">Ganin, Sergei V.</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ivanova%2C+Galina+V%2E%22">Ivanova, Galina V.</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shipilovskikh%2C+Sergei+A%2E%22">Shipilovskikh, Sergei A.</searchLink><relatesTo>1,4</relatesTo> (AUTHOR)<i> s.shipilovskikh@mail.ru</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Applied+Surface+Science%22">Applied Surface Science</searchLink>. Oct2026, Vol. 743, pN.PAG-N.PAG. 1p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Polyvinyl+alcohol%22">Polyvinyl alcohol</searchLink><br /><searchLink fieldCode="DE" term="%22Metal-organic+frameworks%22">Metal-organic frameworks</searchLink><br /><searchLink fieldCode="DE" term="%22Antibacterial+agents%22">Antibacterial agents</searchLink><br /><searchLink fieldCode="DE" term="%22Biocompatibility%22">Biocompatibility</searchLink><br /><searchLink fieldCode="DE" term="%22Antifungal+agents%22">Antifungal agents</searchLink><br /><searchLink fieldCode="DE" term="%22Biomedical+materials%22">Biomedical materials</searchLink><br /><searchLink fieldCode="DE" term="%22Biological+interfaces%22">Biological interfaces</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: [Display omitted] • PVA-based hybrid films incorporated with MOFs were developed by one-pot efficient method. • SEM and optical microscopy revealed morphological changes after MOFs incorporation. • It was determined the influence of incorporated MOFs on mechanical and surface properties of hybrid films. • The hybrid films exhibited excellent antibacterial and antifungal activities compared to individual MOFs. • The hybrid films demonstrated high biocompatibility towards animal model. We design hybrid films made of polyvinyl alcohol (PVA) and HKUST-1 synthesized with efficient in-situ method. It was clearly confirmed in-situ incorporation of HKUST-1 crystals into PVA matrix. It was determined that various percentages of incorporated HKUST-1 (w/v% = 0.1, 0.5, 1 and 2%) have strong influence on surface properties of the developed PVA/HKUST-1 hybrid films. The developed PVA/HKUST-1 (w/v% = 0.1, 0.5, 1 and 2%) hybrid films demonstrated dose-dependent in vitro toxicity. These PVA/HKUST-1 films exhibit excellent antibacterial (Pseudomonas, Escherichia coli, Bacillus subtilis, Serratia marcescens, Klebsiella and Micrococcus) and antifungal activities (Saccharomyces cerevisiae , Rodotorulla rubra and Saccharomyces boulardii). At the same time, no significant side effects were detected, i.e. skin irritation test, blood biochemical analysis and histological analysis of skin tissues did not reveal any pathological factors. In addition, the histological analysis of the main organs (lungs, heart, liver, kidney, and spleen) did not detect any morphological changes of tissues after deposition of PVA/HKUST-1 films onto mouse skin. Finally, all estimated characteristics of efficient and in-situ synthesized PVA/HKUST-1 films are in favor of recommending these materials for preclinical studies. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Applied Surface Science is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=194294497
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.apsusc.2026.167301
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Polyvinyl alcohol
        Type: general
      – SubjectFull: Metal-organic frameworks
        Type: general
      – SubjectFull: Antibacterial agents
        Type: general
      – SubjectFull: Biocompatibility
        Type: general
      – SubjectFull: Antifungal agents
        Type: general
      – SubjectFull: Biomedical materials
        Type: general
      – SubjectFull: Biological interfaces
        Type: general
    Titles:
      – TitleFull: Development of biocompatible MOF-impregnated PVA films with broad-spectrum antimicrobial surface properties by efficient in-situ method.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Timin, Alexander S.
      – PersonEntity:
          Name:
            NameFull: Pochkaeva, Evgeniia I.
      – PersonEntity:
          Name:
            NameFull: Nosova, Natalya A.
      – PersonEntity:
          Name:
            NameFull: Sergeeva, Radmila R.
      – PersonEntity:
          Name:
            NameFull: Brodskaya, Aleksandra V.
      – PersonEntity:
          Name:
            NameFull: Ivanchenko, Olga B.
      – PersonEntity:
          Name:
            NameFull: Nur, Sheila A.
      – PersonEntity:
          Name:
            NameFull: Rogova, Anna
      – PersonEntity:
          Name:
            NameFull: Lipin, Dmitry V.
      – PersonEntity:
          Name:
            NameFull: Ganin, Sergei V.
      – PersonEntity:
          Name:
            NameFull: Ivanova, Galina V.
      – PersonEntity:
          Name:
            NameFull: Shipilovskikh, Sergei A.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 15
              M: 10
              Text: Oct2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 01694332
          Numbering:
            – Type: volume
              Value: 743
          Titles:
            – TitleFull: Applied Surface Science
              Type: main
ResultId 1