Chewable Soft Gelatin Capsules: Design and Formulation Strategies for a Patient‐Preferred Dosage Alternative.
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| Title: | Chewable Soft Gelatin Capsules: Design and Formulation Strategies for a Patient‐Preferred Dosage Alternative. |
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| Authors: | Naharros‐Molinero, Almudena1 (AUTHOR), Caballo‐González, María Ángela1 (AUTHOR), de la Mata, Francisco Javier2,3,4 (AUTHOR), García‐Gallego, Sandra2,3,4 (AUTHOR) sandra.garciagallego@uah.es |
| Source: | Macromolecular Materials & Engineering. Feb2026, Vol. 311 Issue 2, p1-20. 20p. |
| Subjects: | Dosage forms of drugs, Design techniques, Geriatrics, Bioavailability, Patient compliance, Excipients, Pharmaceutical technology |
| Abstract: | Chewable softgels represent a novel dosage form that significantly enhances patient compliance, particularly among pediatric and geriatric populations. This formulation offers advantages such as ease of use and improved swallowing characteristics, as well as an opportunity for enhancement of the sensorial properties of conventional softgel products. Challenges remain in the formulation process for both shell and fill formulation, including the optimization of the shell chewable properties, the selection of active ingredients and excipients for pharma‐ and nutraceutical applications, ensuring bioavailability, and maintaining product stability throughout its shelf life. A critical aspect of development is the implementation of taste masking strategies to improve palatability. Balancing taste masking with the release efficiency of active ingredients is essential for achieving optimal bioavailability and therapeutic effectiveness, thereby improving patient adherence to medication regimens. Ideally, a combination of effective shell formulations, optimized fill formulations, and advanced taste‐masking strategies culminates in the creation of a product that meets therapeutic requirements while being enjoyable for patients to consume. This review aims to offer a guide for pharmaceutical developers in creating chewable softgel formulations that align with modern expectations of patient‐centric medication delivery. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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| Abstract: | Chewable softgels represent a novel dosage form that significantly enhances patient compliance, particularly among pediatric and geriatric populations. This formulation offers advantages such as ease of use and improved swallowing characteristics, as well as an opportunity for enhancement of the sensorial properties of conventional softgel products. Challenges remain in the formulation process for both shell and fill formulation, including the optimization of the shell chewable properties, the selection of active ingredients and excipients for pharma‐ and nutraceutical applications, ensuring bioavailability, and maintaining product stability throughout its shelf life. A critical aspect of development is the implementation of taste masking strategies to improve palatability. Balancing taste masking with the release efficiency of active ingredients is essential for achieving optimal bioavailability and therapeutic effectiveness, thereby improving patient adherence to medication regimens. Ideally, a combination of effective shell formulations, optimized fill formulations, and advanced taste‐masking strategies culminates in the creation of a product that meets therapeutic requirements while being enjoyable for patients to consume. This review aims to offer a guide for pharmaceutical developers in creating chewable softgel formulations that align with modern expectations of patient‐centric medication delivery. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 14387492 |
| DOI: | 10.1002/mame.202500323 |
