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Bifunctionalized core–shell magnetic nanoparticles enabling catalytically amplified chemiluminescence for ultrasensitive detection of pyrophosphate ions.

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Title: Bifunctionalized core–shell magnetic nanoparticles enabling catalytically amplified chemiluminescence for ultrasensitive detection of pyrophosphate ions.
Authors: Ruan, Congwen1,2 (AUTHOR), Tian, Mengchun1,2 (AUTHOR), Gao, Lingfeng1,2 (AUTHOR) lfgao@wtu.edu.cn, Li, Zehao1,2 (AUTHOR) lizehao09@163.com
Source: Microchimica Acta. Jun2026, Vol. 193 Issue 6, p1-11. 11p.
Subjects: Chemiluminescence, Pyrophosphates, Iron oxide nanoparticles, Chemical detectors, Catalysis, Luminol, Biosensors, Magnetic nanoparticles
Abstract: Luminol and Cu2+ bifunctionalized magnetic core-shell Fe3O4@Au nanoparticles (BFCS-Fe3O4@Au NPs) with high chemiluminescence (CL) efficiency were synthesized via an improved approach for pyrophosphate ions (PPi) sensing in complicated samples. First, a uniform Au shell was formed in situ on the Fe3O4 core through the controlled deposition enabled by luminol's reducing property. This process also resulted in the immobilization of luminol molecules on the Au shell via Au-N coordination, where they functioned as the CL signal units. Subsequently, Cysteine (Cys) was modified onto the Fe3O4@Au surface via Au-S bonds, which introduced specific coordination sites for metal ions. Then, Cu2+ were captured by these sites and fixed onto the Fe3O4@Au surface, which efficiently catalyze the luminol-H2O2 reaction, resulting in a strong "signal-on" state. Finally, the presence of PPi could quantitatively quench this signal by competing with Cys for Cu2+ binding, thereby switching the system "off". Due to this "signal-on-off" mechanism, an ultrasensitive sensor for PPi was developed, exhibiting a broad linear detection range from 0.1 nM to 10 µM and a low detection limit of 8.37 pM. This sensing strategy provides a reliable and promising pathway for PPi monitoring in biological analysis and environmental water analysis. [ABSTRACT FROM AUTHOR]
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Database: Engineering Source
Description
Abstract:Luminol and Cu2+ bifunctionalized magnetic core-shell Fe3O4@Au nanoparticles (BFCS-Fe3O4@Au NPs) with high chemiluminescence (CL) efficiency were synthesized via an improved approach for pyrophosphate ions (PPi) sensing in complicated samples. First, a uniform Au shell was formed in situ on the Fe3O4 core through the controlled deposition enabled by luminol's reducing property. This process also resulted in the immobilization of luminol molecules on the Au shell via Au-N coordination, where they functioned as the CL signal units. Subsequently, Cysteine (Cys) was modified onto the Fe3O4@Au surface via Au-S bonds, which introduced specific coordination sites for metal ions. Then, Cu2+ were captured by these sites and fixed onto the Fe3O4@Au surface, which efficiently catalyze the luminol-H2O2 reaction, resulting in a strong "signal-on" state. Finally, the presence of PPi could quantitatively quench this signal by competing with Cys for Cu2+ binding, thereby switching the system "off". Due to this "signal-on-off" mechanism, an ultrasensitive sensor for PPi was developed, exhibiting a broad linear detection range from 0.1 nM to 10 µM and a low detection limit of 8.37 pM. This sensing strategy provides a reliable and promising pathway for PPi monitoring in biological analysis and environmental water analysis. [ABSTRACT FROM AUTHOR]
ISSN:00263672
DOI:10.1007/s00604-026-08096-2