Bifunctionalized core–shell magnetic nanoparticles enabling catalytically amplified chemiluminescence for ultrasensitive detection of pyrophosphate ions.
Saved in:
| Title: | Bifunctionalized core–shell magnetic nanoparticles enabling catalytically amplified chemiluminescence for ultrasensitive detection of pyrophosphate ions. |
|---|---|
| Authors: | Ruan, Congwen1,2 (AUTHOR), Tian, Mengchun1,2 (AUTHOR), Gao, Lingfeng1,2 (AUTHOR) lfgao@wtu.edu.cn, Li, Zehao1,2 (AUTHOR) lizehao09@163.com |
| Source: | Microchimica Acta. Jun2026, Vol. 193 Issue 6, p1-11. 11p. |
| Subjects: | Chemiluminescence, Pyrophosphates, Iron oxide nanoparticles, Chemical detectors, Catalysis, Luminol, Biosensors, Magnetic nanoparticles |
| Abstract: | Luminol and Cu2+ bifunctionalized magnetic core-shell Fe3O4@Au nanoparticles (BFCS-Fe3O4@Au NPs) with high chemiluminescence (CL) efficiency were synthesized via an improved approach for pyrophosphate ions (PPi) sensing in complicated samples. First, a uniform Au shell was formed in situ on the Fe3O4 core through the controlled deposition enabled by luminol's reducing property. This process also resulted in the immobilization of luminol molecules on the Au shell via Au-N coordination, where they functioned as the CL signal units. Subsequently, Cysteine (Cys) was modified onto the Fe3O4@Au surface via Au-S bonds, which introduced specific coordination sites for metal ions. Then, Cu2+ were captured by these sites and fixed onto the Fe3O4@Au surface, which efficiently catalyze the luminol-H2O2 reaction, resulting in a strong "signal-on" state. Finally, the presence of PPi could quantitatively quench this signal by competing with Cys for Cu2+ binding, thereby switching the system "off". Due to this "signal-on-off" mechanism, an ultrasensitive sensor for PPi was developed, exhibiting a broad linear detection range from 0.1 nM to 10 µM and a low detection limit of 8.37 pM. This sensing strategy provides a reliable and promising pathway for PPi monitoring in biological analysis and environmental water analysis. [ABSTRACT FROM AUTHOR] |
| Copyright of Microchimica Acta is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: egs DbLabel: Engineering Source An: 194722251 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Bifunctionalized core–shell magnetic nanoparticles enabling catalytically amplified chemiluminescence for ultrasensitive detection of pyrophosphate ions. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ruan%2C+Congwen%22">Ruan, Congwen</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tian%2C+Mengchun%22">Tian, Mengchun</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gao%2C+Lingfeng%22">Gao, Lingfeng</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> lfgao@wtu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22Li%2C+Zehao%22">Li, Zehao</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> lizehao09@163.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Microchimica+Acta%22">Microchimica Acta</searchLink>. Jun2026, Vol. 193 Issue 6, p1-11. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Chemiluminescence%22">Chemiluminescence</searchLink><br /><searchLink fieldCode="DE" term="%22Pyrophosphates%22">Pyrophosphates</searchLink><br /><searchLink fieldCode="DE" term="%22Iron+oxide+nanoparticles%22">Iron oxide nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Chemical+detectors%22">Chemical detectors</searchLink><br /><searchLink fieldCode="DE" term="%22Catalysis%22">Catalysis</searchLink><br /><searchLink fieldCode="DE" term="%22Luminol%22">Luminol</searchLink><br /><searchLink fieldCode="DE" term="%22Biosensors%22">Biosensors</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+nanoparticles%22">Magnetic nanoparticles</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Luminol and Cu2+ bifunctionalized magnetic core-shell Fe3O4@Au nanoparticles (BFCS-Fe3O4@Au NPs) with high chemiluminescence (CL) efficiency were synthesized via an improved approach for pyrophosphate ions (PPi) sensing in complicated samples. First, a uniform Au shell was formed in situ on the Fe3O4 core through the controlled deposition enabled by luminol's reducing property. This process also resulted in the immobilization of luminol molecules on the Au shell via Au-N coordination, where they functioned as the CL signal units. Subsequently, Cysteine (Cys) was modified onto the Fe3O4@Au surface via Au-S bonds, which introduced specific coordination sites for metal ions. Then, Cu2+ were captured by these sites and fixed onto the Fe3O4@Au surface, which efficiently catalyze the luminol-H2O2 reaction, resulting in a strong "signal-on" state. Finally, the presence of PPi could quantitatively quench this signal by competing with Cys for Cu2+ binding, thereby switching the system "off". Due to this "signal-on-off" mechanism, an ultrasensitive sensor for PPi was developed, exhibiting a broad linear detection range from 0.1 nM to 10 µM and a low detection limit of 8.37 pM. This sensing strategy provides a reliable and promising pathway for PPi monitoring in biological analysis and environmental water analysis. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Microchimica Acta is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=194722251 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00604-026-08096-2 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 1 Subjects: – SubjectFull: Chemiluminescence Type: general – SubjectFull: Pyrophosphates Type: general – SubjectFull: Iron oxide nanoparticles Type: general – SubjectFull: Chemical detectors Type: general – SubjectFull: Catalysis Type: general – SubjectFull: Luminol Type: general – SubjectFull: Biosensors Type: general – SubjectFull: Magnetic nanoparticles Type: general Titles: – TitleFull: Bifunctionalized core–shell magnetic nanoparticles enabling catalytically amplified chemiluminescence for ultrasensitive detection of pyrophosphate ions. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ruan, Congwen – PersonEntity: Name: NameFull: Tian, Mengchun – PersonEntity: Name: NameFull: Gao, Lingfeng – PersonEntity: Name: NameFull: Li, Zehao IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 00263672 Numbering: – Type: volume Value: 193 – Type: issue Value: 6 Titles: – TitleFull: Microchimica Acta Type: main |
| ResultId | 1 |
