Highly Selective Interfacial Route to Eight-Functional Sucrose Methacrylate for Biocompatible Scaffold Fabrication.
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| Title: | Highly Selective Interfacial Route to Eight-Functional Sucrose Methacrylate for Biocompatible Scaffold Fabrication. |
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| Authors: | Kaplin, Vladislav1 (AUTHOR) piroklas@gmail.com, Glagolev, Nikolay1,2 (AUTHOR), Minaev, Nikita2,3 (AUTHOR), Epifanov, Evgenii2,4 (AUTHOR), Aksenova, Nadezhda1,3,5 (AUTHOR), Akovantseva, Anastasiia1,6 (AUTHOR), Zarkhina, Tatyana1 (AUTHOR), Vasileva, Olga2,4 (AUTHOR), Kiseleva, Elena1,3 (AUTHOR), Zimens, Marina4,5,6 (AUTHOR), Kuryanova, Anastasia1,5 (AUTHOR), Mukhametova, Gulnaz1,6 (AUTHOR), Solovieva, Anna1 (AUTHOR) |
| Source: | Polymers (20734360). Jun2026, Vol. 18 Issue 12, p1417. 17p. |
| Subjects: | Urethane, Crosslinked polymers, Photochemical curing, Biomimetic materials, Three-dimensional printing, Bone substitutes |
| Abstract: | The synthesis of reactive sucrose derivatives is of significant interest for the development of novel biocompatible polymers. In this study, an octa-substituted sucrose derivative containing isocyanate groups was synthesized via a urethane-forming reaction carried out in an aprotic solvent at the phase interface. This approach exhibits high selectivity and provides a target product yield of up to 60%. Subsequently, using the same reaction mechanism, the isocyanate derivative was converted into an octa-functional methacrylate derivative capable of forming three-dimensional cross-linked networks. The structures of both the intermediate and final products were confirmed by IR, 1H NMR, and mass spectrometry. The sucrose-based prepolymer was further evaluated in the formation of cross-linked structures for potential application as bone-substituting implants. Using various photocuring techniques, including two-photon 3D printing, both plates and microstructured scaffolds were fabricated. These structures exhibited high thermal stability, elastic properties comparable to those of bone tissue, and no toxic effects on cells. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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| Abstract: | The synthesis of reactive sucrose derivatives is of significant interest for the development of novel biocompatible polymers. In this study, an octa-substituted sucrose derivative containing isocyanate groups was synthesized via a urethane-forming reaction carried out in an aprotic solvent at the phase interface. This approach exhibits high selectivity and provides a target product yield of up to 60%. Subsequently, using the same reaction mechanism, the isocyanate derivative was converted into an octa-functional methacrylate derivative capable of forming three-dimensional cross-linked networks. The structures of both the intermediate and final products were confirmed by IR, 1H NMR, and mass spectrometry. The sucrose-based prepolymer was further evaluated in the formation of cross-linked structures for potential application as bone-substituting implants. Using various photocuring techniques, including two-photon 3D printing, both plates and microstructured scaffolds were fabricated. These structures exhibited high thermal stability, elastic properties comparable to those of bone tissue, and no toxic effects on cells. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 20734360 |
| DOI: | 10.3390/polym18121417 |
