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Highly Selective Interfacial Route to Eight-Functional Sucrose Methacrylate for Biocompatible Scaffold Fabrication.

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Title: Highly Selective Interfacial Route to Eight-Functional Sucrose Methacrylate for Biocompatible Scaffold Fabrication.
Authors: Kaplin, Vladislav1 (AUTHOR) piroklas@gmail.com, Glagolev, Nikolay1,2 (AUTHOR), Minaev, Nikita2,3 (AUTHOR), Epifanov, Evgenii2,4 (AUTHOR), Aksenova, Nadezhda1,3,5 (AUTHOR), Akovantseva, Anastasiia1,6 (AUTHOR), Zarkhina, Tatyana1 (AUTHOR), Vasileva, Olga2,4 (AUTHOR), Kiseleva, Elena1,3 (AUTHOR), Zimens, Marina4,5,6 (AUTHOR), Kuryanova, Anastasia1,5 (AUTHOR), Mukhametova, Gulnaz1,6 (AUTHOR), Solovieva, Anna1 (AUTHOR)
Source: Polymers (20734360). Jun2026, Vol. 18 Issue 12, p1417. 17p.
Subjects: Urethane, Crosslinked polymers, Photochemical curing, Biomimetic materials, Three-dimensional printing, Bone substitutes
Abstract: The synthesis of reactive sucrose derivatives is of significant interest for the development of novel biocompatible polymers. In this study, an octa-substituted sucrose derivative containing isocyanate groups was synthesized via a urethane-forming reaction carried out in an aprotic solvent at the phase interface. This approach exhibits high selectivity and provides a target product yield of up to 60%. Subsequently, using the same reaction mechanism, the isocyanate derivative was converted into an octa-functional methacrylate derivative capable of forming three-dimensional cross-linked networks. The structures of both the intermediate and final products were confirmed by IR, 1H NMR, and mass spectrometry. The sucrose-based prepolymer was further evaluated in the formation of cross-linked structures for potential application as bone-substituting implants. Using various photocuring techniques, including two-photon 3D printing, both plates and microstructured scaffolds were fabricated. These structures exhibited high thermal stability, elastic properties comparable to those of bone tissue, and no toxic effects on cells. [ABSTRACT FROM AUTHOR]
Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Highly Selective Interfacial Route to Eight-Functional Sucrose Methacrylate for Biocompatible Scaffold Fabrication.
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  Data: <searchLink fieldCode="AR" term="%22Kaplin%2C+Vladislav%22">Kaplin, Vladislav</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> piroklas@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Glagolev%2C+Nikolay%22">Glagolev, Nikolay</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Minaev%2C+Nikita%22">Minaev, Nikita</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Epifanov%2C+Evgenii%22">Epifanov, Evgenii</searchLink><relatesTo>2,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aksenova%2C+Nadezhda%22">Aksenova, Nadezhda</searchLink><relatesTo>1,3,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Akovantseva%2C+Anastasiia%22">Akovantseva, Anastasiia</searchLink><relatesTo>1,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zarkhina%2C+Tatyana%22">Zarkhina, Tatyana</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vasileva%2C+Olga%22">Vasileva, Olga</searchLink><relatesTo>2,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kiseleva%2C+Elena%22">Kiseleva, Elena</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zimens%2C+Marina%22">Zimens, Marina</searchLink><relatesTo>4,5,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kuryanova%2C+Anastasia%22">Kuryanova, Anastasia</searchLink><relatesTo>1,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mukhametova%2C+Gulnaz%22">Mukhametova, Gulnaz</searchLink><relatesTo>1,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Solovieva%2C+Anna%22">Solovieva, Anna</searchLink><relatesTo>1</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Polymers+%2820734360%29%22">Polymers (20734360)</searchLink>. Jun2026, Vol. 18 Issue 12, p1417. 17p.
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  Data: <searchLink fieldCode="DE" term="%22Urethane%22">Urethane</searchLink><br /><searchLink fieldCode="DE" term="%22Crosslinked+polymers%22">Crosslinked polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Photochemical+curing%22">Photochemical curing</searchLink><br /><searchLink fieldCode="DE" term="%22Biomimetic+materials%22">Biomimetic materials</searchLink><br /><searchLink fieldCode="DE" term="%22Three-dimensional+printing%22">Three-dimensional printing</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+substitutes%22">Bone substitutes</searchLink>
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  Label: Abstract
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  Data: The synthesis of reactive sucrose derivatives is of significant interest for the development of novel biocompatible polymers. In this study, an octa-substituted sucrose derivative containing isocyanate groups was synthesized via a urethane-forming reaction carried out in an aprotic solvent at the phase interface. This approach exhibits high selectivity and provides a target product yield of up to 60%. Subsequently, using the same reaction mechanism, the isocyanate derivative was converted into an octa-functional methacrylate derivative capable of forming three-dimensional cross-linked networks. The structures of both the intermediate and final products were confirmed by IR, 1H NMR, and mass spectrometry. The sucrose-based prepolymer was further evaluated in the formation of cross-linked structures for potential application as bone-substituting implants. Using various photocuring techniques, including two-photon 3D printing, both plates and microstructured scaffolds were fabricated. These structures exhibited high thermal stability, elastic properties comparable to those of bone tissue, and no toxic effects on cells. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3390/polym18121417
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      – Code: eng
        Text: English
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        PageCount: 17
        StartPage: 1417
    Subjects:
      – SubjectFull: Urethane
        Type: general
      – SubjectFull: Crosslinked polymers
        Type: general
      – SubjectFull: Photochemical curing
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      – SubjectFull: Biomimetic materials
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      – SubjectFull: Three-dimensional printing
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      – SubjectFull: Bone substitutes
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      – TitleFull: Highly Selective Interfacial Route to Eight-Functional Sucrose Methacrylate for Biocompatible Scaffold Fabrication.
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              M: 06
              Text: Jun2026
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