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Phase-controlled synthesis of Ca-Mg-Si bioceramics: Deciphering the impact of evaporation and temperature on mechanical-biological synergy.

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Title: Phase-controlled synthesis of Ca-Mg-Si bioceramics: Deciphering the impact of evaporation and temperature on mechanical-biological synergy.
Authors: Yang, Yu-Tong1 (AUTHOR), Wang, Sin-Jhang1,2 (AUTHOR), Tseng, Yu-Sheng1 (AUTHOR), Chen, Wen-Fan1 (AUTHOR) sallychen@imst.nsysu.edu.tw
Source: Ceramics International. Jul2026, Vol. 52 Issue 18, p34011-34024. 14p.
Subjects: Diopside, Tissue engineering, Mechanical behavior of materials
Abstract: This study systematically engineers Ca-Mg-Si bioceramics with tunable phase compositions by modulating synthesis temperature and evaporation kinetics. A controllable framework to transition from single-phase diopside (D) to multi-phase systems incorporating akermanite (DA) and merwinite (DAM) was established. The results demonstrate that pure diopside ensures superior mechanical integrity with a high hardness of 2918 ± 89 MPa and low porosity (6.29 ± 1.01%). Strategically incorporating secondary phases allows for fine-tuning degradation; notably, dual-phase DA ceramics maintained robust structural stability with a low hardness reduction rate of 11.6% after 28-day SBF immersion, while exhibiting superior bioactivity with 5-10 μm HAp clusters completely masking the substrate. In contrast, rapid ion release from DAM groups favored amorphous precursors, hindering mature HAp crystallization. Biological assays with MC3T3-E1 cells confirmed that D and DA groups supported over 70% viability and significantly enhanced late-stage mineralization compared to the control. This research provides a definitive phase-distribution map, offering a precise guide for fabricating bioceramic scaffolds that balance high densification with optimized osteoinductive performance for bone tissue engineering. [ABSTRACT FROM AUTHOR]
Copyright of Ceramics International is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
An: 194968252
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  Label: Title
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  Data: Phase-controlled synthesis of Ca-Mg-Si bioceramics: Deciphering the impact of evaporation and temperature on mechanical-biological synergy.
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  Data: <searchLink fieldCode="AR" term="%22Yang%2C+Yu-Tong%22">Yang, Yu-Tong</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Sin-Jhang%22">Wang, Sin-Jhang</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tseng%2C+Yu-Sheng%22">Tseng, Yu-Sheng</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Wen-Fan%22">Chen, Wen-Fan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> sallychen@imst.nsysu.edu.tw</i>
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  Data: <searchLink fieldCode="JN" term="%22Ceramics+International%22">Ceramics International</searchLink>. Jul2026, Vol. 52 Issue 18, p34011-34024. 14p.
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  Data: <searchLink fieldCode="DE" term="%22Diopside%22">Diopside</searchLink><br /><searchLink fieldCode="DE" term="%22Tissue+engineering%22">Tissue engineering</searchLink><br /><searchLink fieldCode="DE" term="%22Mechanical+behavior+of+materials%22">Mechanical behavior of materials</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: This study systematically engineers Ca-Mg-Si bioceramics with tunable phase compositions by modulating synthesis temperature and evaporation kinetics. A controllable framework to transition from single-phase diopside (D) to multi-phase systems incorporating akermanite (DA) and merwinite (DAM) was established. The results demonstrate that pure diopside ensures superior mechanical integrity with a high hardness of 2918 ± 89 MPa and low porosity (6.29 ± 1.01%). Strategically incorporating secondary phases allows for fine-tuning degradation; notably, dual-phase DA ceramics maintained robust structural stability with a low hardness reduction rate of 11.6% after 28-day SBF immersion, while exhibiting superior bioactivity with 5-10 μm HAp clusters completely masking the substrate. In contrast, rapid ion release from DAM groups favored amorphous precursors, hindering mature HAp crystallization. Biological assays with MC3T3-E1 cells confirmed that D and DA groups supported over 70% viability and significantly enhanced late-stage mineralization compared to the control. This research provides a definitive phase-distribution map, offering a precise guide for fabricating bioceramic scaffolds that balance high densification with optimized osteoinductive performance for bone tissue engineering. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Ceramics International is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.ceramint.2026.05.432
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      – Code: eng
        Text: English
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        PageCount: 14
        StartPage: 34011
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        Type: general
      – SubjectFull: Tissue engineering
        Type: general
      – SubjectFull: Mechanical behavior of materials
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      – TitleFull: Phase-controlled synthesis of Ca-Mg-Si bioceramics: Deciphering the impact of evaporation and temperature on mechanical-biological synergy.
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            NameFull: Yang, Yu-Tong
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            NameFull: Wang, Sin-Jhang
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            NameFull: Tseng, Yu-Sheng
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            – D: 06
              M: 07
              Text: Jul2026
              Type: published
              Y: 2026
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