Continuous flow synthesis of α-lipoic acid using microreactors.
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| Title: | Continuous flow synthesis of α-lipoic acid using microreactors. |
|---|---|
| Authors: | Manthani, Navya1,2 (AUTHOR), Latchubugata, Chandra Sekhar1 (AUTHOR), Pabbaraja, Srihari2 (AUTHOR), Vedantam, Sreepriya1,2 (AUTHOR) sreepriya@iict.res.in |
| Source: | Sādhanā: Academy Proceedings in Engineering Sciences. Sep2026, Vol. 51 Issue 3, p1-11. 11p. |
| Subjects: | Microreactors, Flow chemistry, Kinetic control, Lipoic acid, Chemical processes, Computational fluid dynamics |
| Abstract: | In recent years, micro-fluidic reactor technology has proven to be an effective tool for process chemistry in the chemical, biological, and engineering sciences. Continuous flow chemistry is a process-intensified method that precisely controls reaction rate, scales up synthesis, and produces products with maximum yields as compared to traditional synthesis under one-pot solution processing conditions. The current study has established a continuous multistep flow synthesis of Alpha Lipoic Acid (ALA), a naturally occurring antioxidant. Research has been carried out to understand the effects of crucial operating factors such as residence time, solvent ratio, reaction temperature and the effect of geometry. In this study, we have concentrated on the important role that reactor geometry plays in improving mixing efficiency. Numerical methods employing Computational Fluid Dynamics (CFD) tools are used to understand the velocity and pressure profiles, residence times to comprehend the mechanism of mixing. When compared to a channel alone, it was demonstrated that the improved geometry produced a sharp distribution curve. In order, to improve the final yields, a modified reactor design that uses enhancers and reducers is used. When ALA was synthesized using enhanced technology in microreactors, the yield was 71.4% with a selectivity of >99%. [ABSTRACT FROM AUTHOR] |
| Copyright of Sādhanā: Academy Proceedings in Engineering Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Items | – Name: Title Label: Title Group: Ti Data: Continuous flow synthesis of α-lipoic acid using microreactors. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Manthani%2C+Navya%22">Manthani, Navya</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Latchubugata%2C+Chandra+Sekhar%22">Latchubugata, Chandra Sekhar</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pabbaraja%2C+Srihari%22">Pabbaraja, Srihari</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vedantam%2C+Sreepriya%22">Vedantam, Sreepriya</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> sreepriya@iict.res.in</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Sādhanā%3A+Academy+Proceedings+in+Engineering+Sciences%22">Sādhanā: Academy Proceedings in Engineering Sciences</searchLink>. Sep2026, Vol. 51 Issue 3, p1-11. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Microreactors%22">Microreactors</searchLink><br /><searchLink fieldCode="DE" term="%22Flow+chemistry%22">Flow chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Kinetic+control%22">Kinetic control</searchLink><br /><searchLink fieldCode="DE" term="%22Lipoic+acid%22">Lipoic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Chemical+processes%22">Chemical processes</searchLink><br /><searchLink fieldCode="DE" term="%22Computational+fluid+dynamics%22">Computational fluid dynamics</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: In recent years, micro-fluidic reactor technology has proven to be an effective tool for process chemistry in the chemical, biological, and engineering sciences. Continuous flow chemistry is a process-intensified method that precisely controls reaction rate, scales up synthesis, and produces products with maximum yields as compared to traditional synthesis under one-pot solution processing conditions. The current study has established a continuous multistep flow synthesis of Alpha Lipoic Acid (ALA), a naturally occurring antioxidant. Research has been carried out to understand the effects of crucial operating factors such as residence time, solvent ratio, reaction temperature and the effect of geometry. In this study, we have concentrated on the important role that reactor geometry plays in improving mixing efficiency. Numerical methods employing Computational Fluid Dynamics (CFD) tools are used to understand the velocity and pressure profiles, residence times to comprehend the mechanism of mixing. When compared to a channel alone, it was demonstrated that the improved geometry produced a sharp distribution curve. In order, to improve the final yields, a modified reactor design that uses enhancers and reducers is used. When ALA was synthesized using enhanced technology in microreactors, the yield was 71.4% with a selectivity of >99%. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Sādhanā: Academy Proceedings in Engineering Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s12046-026-03198-2 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 1 Subjects: – SubjectFull: Microreactors Type: general – SubjectFull: Flow chemistry Type: general – SubjectFull: Kinetic control Type: general – SubjectFull: Lipoic acid Type: general – SubjectFull: Chemical processes Type: general – SubjectFull: Computational fluid dynamics Type: general Titles: – TitleFull: Continuous flow synthesis of α-lipoic acid using microreactors. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Manthani, Navya – PersonEntity: Name: NameFull: Latchubugata, Chandra Sekhar – PersonEntity: Name: NameFull: Pabbaraja, Srihari – PersonEntity: Name: NameFull: Vedantam, Sreepriya IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 02562499 Numbering: – Type: volume Value: 51 – Type: issue Value: 3 Titles: – TitleFull: Sādhanā: Academy Proceedings in Engineering Sciences Type: main |
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