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Simultaneous analysis of antioxidants and preservatives in cosmetics by supercritical fluid extraction combined with liquid chromatography–mass spectrometry

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Title: Simultaneous analysis of antioxidants and preservatives in cosmetics by supercritical fluid extraction combined with liquid chromatography–mass spectrometry
Authors: Lee, Maw-Rong1 mrlee@mail.nchu.edu.tw, Lin, Chueh-Yu1, Li, Zu-Guang1,2, Tsai, Tzu-Feng1
Source: Journal of Chromatography A. Jul2006, Vol. 1120 Issue 1/2, p244-251. 8p.
Subjects: Fluids, Chemical inhibitors, Supercritical fluids, Mass spectrometry
Abstract: Abstract: This study evaluated supercritical fluid extraction (SFE) combined with liquid chromatography–mass spectrometry (LC–MS) to determine trace preservatives and antioxidants including methylparaben (MP), ethylparaben (EP), propylparaben (PP), butylparaben (BP), butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), α-tocopherol (α-t) and α-tocopherol acetate (α-ta) in cosmetic products. A supercritical fluid extraction procedure was used to isolate four paraben preservatives and four antioxidants from the cosmetic matrix before quantitative analysis. The optimum extraction condition was performed with static extraction for 5min, then dynamic extraction for 20min by using carbon dioxide supercritical fluid at 14,000kPa and 65°C. Methanol was used as collection solvent and the sea sand was chosen as a filling material. The analytes were separated on a C18 reversed-phase column using methanol–water as mobile phase and quantified by measuring its mass spectrometry. The linearity range is from 10 to 20,000ng/g with RSD values below 18%. Detection limits are achieved at the level of 4.7–142ng/g. It was successfully applied to the determination of paraben preservatives and antioxidants in cosmetics without tedious pretreatment. [Copyright &y& Elsevier]
Copyright of Journal of Chromatography A is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
An: 21188950
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  Label: Title
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  Data: Simultaneous analysis of antioxidants and preservatives in cosmetics by supercritical fluid extraction combined with liquid chromatography–mass spectrometry
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  Data: <searchLink fieldCode="AR" term="%22Lee%2C+Maw-Rong%22">Lee, Maw-Rong</searchLink><relatesTo>1</relatesTo><i> mrlee@mail.nchu.edu.tw</i><br /><searchLink fieldCode="AR" term="%22Lin%2C+Chueh-Yu%22">Lin, Chueh-Yu</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Li%2C+Zu-Guang%22">Li, Zu-Guang</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Tsai%2C+Tzu-Feng%22">Tsai, Tzu-Feng</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Chromatography+A%22">Journal of Chromatography A</searchLink>. Jul2006, Vol. 1120 Issue 1/2, p244-251. 8p.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Fluids%22">Fluids</searchLink><br /><searchLink fieldCode="DE" term="%22Chemical+inhibitors%22">Chemical inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Supercritical+fluids%22">Supercritical fluids</searchLink><br /><searchLink fieldCode="DE" term="%22Mass+spectrometry%22">Mass spectrometry</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Abstract: This study evaluated supercritical fluid extraction (SFE) combined with liquid chromatography–mass spectrometry (LC–MS) to determine trace preservatives and antioxidants including methylparaben (MP), ethylparaben (EP), propylparaben (PP), butylparaben (BP), butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), α-tocopherol (α-t) and α-tocopherol acetate (α-ta) in cosmetic products. A supercritical fluid extraction procedure was used to isolate four paraben preservatives and four antioxidants from the cosmetic matrix before quantitative analysis. The optimum extraction condition was performed with static extraction for 5min, then dynamic extraction for 20min by using carbon dioxide supercritical fluid at 14,000kPa and 65°C. Methanol was used as collection solvent and the sea sand was chosen as a filling material. The analytes were separated on a C18 reversed-phase column using methanol–water as mobile phase and quantified by measuring its mass spectrometry. The linearity range is from 10 to 20,000ng/g with RSD values below 18%. Detection limits are achieved at the level of 4.7–142ng/g. It was successfully applied to the determination of paraben preservatives and antioxidants in cosmetics without tedious pretreatment. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Chromatography A is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.chroma.2006.01.075
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      – Code: eng
        Text: English
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        StartPage: 244
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      – SubjectFull: Fluids
        Type: general
      – SubjectFull: Chemical inhibitors
        Type: general
      – SubjectFull: Supercritical fluids
        Type: general
      – SubjectFull: Mass spectrometry
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      – TitleFull: Simultaneous analysis of antioxidants and preservatives in cosmetics by supercritical fluid extraction combined with liquid chromatography–mass spectrometry
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            NameFull: Lee, Maw-Rong
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            NameFull: Lin, Chueh-Yu
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            NameFull: Li, Zu-Guang
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            NameFull: Tsai, Tzu-Feng
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            – D: 07
              M: 07
              Text: Jul2006
              Type: published
              Y: 2006
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            – TitleFull: Journal of Chromatography A
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