Bibliographic Details
| Title: |
Oxidative damage of periodontal tissue in the rat periodontitis model: Effects of a high-cholesterol diet |
| Authors: |
Tomofuji, Takaaki1, Azuma, Tetsuji1, Kusano, Hiroki1, Sanbe, Toshihiro1, Ekuni, Daisuke1, Tamaki, Naofumi1, Yamamoto, Tatsuo1, Watanabe, Tatsuo wyobou@md.okayama-u.ac.jp |
| Source: |
FEBS Letters. Jun2006, Vol. 580 Issue 15, p3601-3604. 4p. |
| Subjects: |
Cholesterol, Periodontitis, Diet, Isopentenoids |
| Abstract: |
Abstract: Studies suggest an association between consumption of a high-cholesterol diet and periodontitis. We addressed the mechanism by which high dietary cholesterol could be detrimental to periodontal health in a rat model. Feeding a high-cholesterol diet augmented the effects of bacterial pathogens and their products (e.g., lipopolysaccharide and proteases) on production of pro-inflammatory cytokines in fibroblasts. High dietary cholesterol also increased mitochondrial 8-hydroxydeoxyguanosine in the periodontal tissues. These results suggest that excessive tissue oxidative damage induced by high dietary cholesterol could potentiate pro-inflammatory cytokine production by fibroblasts stimulated with bacterial pathogens. [Copyright &y& Elsevier] |
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| Database: |
Engineering Source |
