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Oxidative damage of periodontal tissue in the rat periodontitis model: Effects of a high-cholesterol diet

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Title: Oxidative damage of periodontal tissue in the rat periodontitis model: Effects of a high-cholesterol diet
Authors: Tomofuji, Takaaki1, Azuma, Tetsuji1, Kusano, Hiroki1, Sanbe, Toshihiro1, Ekuni, Daisuke1, Tamaki, Naofumi1, Yamamoto, Tatsuo1, Watanabe, Tatsuo wyobou@md.okayama-u.ac.jp
Source: FEBS Letters. Jun2006, Vol. 580 Issue 15, p3601-3604. 4p.
Subjects: Cholesterol, Periodontitis, Diet, Isopentenoids
Abstract: Abstract: Studies suggest an association between consumption of a high-cholesterol diet and periodontitis. We addressed the mechanism by which high dietary cholesterol could be detrimental to periodontal health in a rat model. Feeding a high-cholesterol diet augmented the effects of bacterial pathogens and their products (e.g., lipopolysaccharide and proteases) on production of pro-inflammatory cytokines in fibroblasts. High dietary cholesterol also increased mitochondrial 8-hydroxydeoxyguanosine in the periodontal tissues. These results suggest that excessive tissue oxidative damage induced by high dietary cholesterol could potentiate pro-inflammatory cytokine production by fibroblasts stimulated with bacterial pathogens. [Copyright &y& Elsevier]
Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 21190219
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Oxidative damage of periodontal tissue in the rat periodontitis model: Effects of a high-cholesterol diet
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  Data: <searchLink fieldCode="AR" term="%22Tomofuji%2C+Takaaki%22">Tomofuji, Takaaki</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Azuma%2C+Tetsuji%22">Azuma, Tetsuji</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kusano%2C+Hiroki%22">Kusano, Hiroki</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Sanbe%2C+Toshihiro%22">Sanbe, Toshihiro</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ekuni%2C+Daisuke%22">Ekuni, Daisuke</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Tamaki%2C+Naofumi%22">Tamaki, Naofumi</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Yamamoto%2C+Tatsuo%22">Yamamoto, Tatsuo</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Watanabe%2C+Tatsuo%22">Watanabe, Tatsuo</searchLink><i> wyobou@md.okayama-u.ac.jp</i>
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  Data: <searchLink fieldCode="JN" term="%22FEBS+Letters%22">FEBS Letters</searchLink>. Jun2006, Vol. 580 Issue 15, p3601-3604. 4p.
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  Data: <searchLink fieldCode="DE" term="%22Cholesterol%22">Cholesterol</searchLink><br /><searchLink fieldCode="DE" term="%22Periodontitis%22">Periodontitis</searchLink><br /><searchLink fieldCode="DE" term="%22Diet%22">Diet</searchLink><br /><searchLink fieldCode="DE" term="%22Isopentenoids%22">Isopentenoids</searchLink>
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  Data: Abstract: Studies suggest an association between consumption of a high-cholesterol diet and periodontitis. We addressed the mechanism by which high dietary cholesterol could be detrimental to periodontal health in a rat model. Feeding a high-cholesterol diet augmented the effects of bacterial pathogens and their products (e.g., lipopolysaccharide and proteases) on production of pro-inflammatory cytokines in fibroblasts. High dietary cholesterol also increased mitochondrial 8-hydroxydeoxyguanosine in the periodontal tissues. These results suggest that excessive tissue oxidative damage induced by high dietary cholesterol could potentiate pro-inflammatory cytokine production by fibroblasts stimulated with bacterial pathogens. [Copyright &y& Elsevier]
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  Data: <i>Copyright of FEBS Letters is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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