The revenge of the Patterson methods. II. Substructure applications.

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Bibliographic Details
Title:	The revenge of the Patterson methods. II. Substructure applications.
Authors:	Burla, Maria Cristina¹, Caliandro, Rocco², Carrozzini, Benedetta², Cascarano, Giovanni Luca², De Caro, Liberato², Giacovazzo, Carmelo^2,3 carmelo.giacovazzo@ic.cnr.it, Polidori, Giampiero¹, Siliqi, Dritan²
Source:	Journal of Applied Crystallography. Apr2007, Vol. 40 Issue 2, p211-217. 7p. 4 Charts, 4 Graphs.
Subjects:	Patterson function, Crystallography, Optical diffraction, Electron distribution, Wavelengths
Abstract:	The Patterson techniques, recently developed by the same authors for the ab initio crystal structure solution of proteins, have been applied to single and multiple anomalous diffraction (SAD and MAD) data to find the substructure of the anomalous scatterers. An automatic procedure has been applied to a large set of test structures, some of which were originally solved with remarkable difficulty. In all cases, the procedure automatically leads to interpretable electron density maps. Patterson techniques have been compared with direct methods; the former seem to be more efficient than the latter, so confirming the results obtained for ab initio phasing, and disproving the common belief that they could only be applied to determine large equal-atom substructures with difficulty. [ABSTRACT FROM AUTHOR]
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Database:	Engineering Source

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Abstract:	The Patterson techniques, recently developed by the same authors for the ab initio crystal structure solution of proteins, have been applied to single and multiple anomalous diffraction (SAD and MAD) data to find the substructure of the anomalous scatterers. An automatic procedure has been applied to a large set of test structures, some of which were originally solved with remarkable difficulty. In all cases, the procedure automatically leads to interpretable electron density maps. Patterson techniques have been compared with direct methods; the former seem to be more efficient than the latter, so confirming the results obtained for ab initio phasing, and disproving the common belief that they could only be applied to determine large equal-atom substructures with difficulty. [ABSTRACT FROM AUTHOR]
ISSN:	00218898
DOI:	10.1107/S0021889806052058