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Measurements of deposited dose with induced β+ activity in proton and heavy-ion therapy

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Title: Measurements of deposited dose with induced β+ activity in proton and heavy-ion therapy
Authors: Inaniwa, T.1 taku@nirs.go.jp, Kohno, T.1, Tomitani, T.2, Urakabe, E.3, Sato, S.2, Kanazawa, M.2, Kanai, T.2
Source: Nuclear Instruments & Methods in Physics Research Section A. Oct2007, Vol. 580 Issue 2, p1140-1143. 4p.
Subjects: Cancer treatment, Intermediates (Chemistry), Irradiation, Electrons
Abstract: Abstract: For the effective utilization of the favorable properties of heavy-ion beams in cancer treatment, it is important to evaluate the range of incident ions and the deposited dose distribution in a patient''s body. For this purpose, the utilization of positron emitters induced in therapeutic irradiation is, at present, the only feasible method for in situ and non-invasive monitoring of heavy-ion therapy. In this study, we performed irradiation experiments with three species of ions to a water target, and the annihilation gamma-ray distributions were obtained with a positron camera. We applied the maximum likelihood estimation (MLE) method for the detected distributions to derive the range of incident ions and the deposited dose distribution in the target. As a result, the ranges were determined with a difference between the MLE range R MLE and the experimental range R exp less than 1.1mm. The good agreement between the estimated dose distribution with the MLE method and the measured one implies that a deposited dose distribution in a target could be estimated from a detected annihilation gamma-ray distribution. [Copyright &y& Elsevier]
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Database: Engineering Source
Description
Abstract:Abstract: For the effective utilization of the favorable properties of heavy-ion beams in cancer treatment, it is important to evaluate the range of incident ions and the deposited dose distribution in a patient''s body. For this purpose, the utilization of positron emitters induced in therapeutic irradiation is, at present, the only feasible method for in situ and non-invasive monitoring of heavy-ion therapy. In this study, we performed irradiation experiments with three species of ions to a water target, and the annihilation gamma-ray distributions were obtained with a positron camera. We applied the maximum likelihood estimation (MLE) method for the detected distributions to derive the range of incident ions and the deposited dose distribution in the target. As a result, the ranges were determined with a difference between the MLE range R MLE and the experimental range R exp less than 1.1mm. The good agreement between the estimated dose distribution with the MLE method and the measured one implies that a deposited dose distribution in a target could be estimated from a detected annihilation gamma-ray distribution. [Copyright &y& Elsevier]
ISSN:01689002
DOI:10.1016/j.nima.2007.06.072