Bibliographic Details
| Title: |
A practical route for synthesizing a PET ligand containing [18F]fluorobenzene using reaction of diphenyliodonium salt with [18F]F− |
| Authors: |
Zhang, Ming-Rong zhang@nirs.go.jp, Kumata, Katsushi1, Suzuki, Kazutoshi1 |
| Source: |
Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Dec2007, Vol. 48 Issue 49, p8632-8635. 4p. |
| Subjects: |
Research, Polyethylene terephthalate, Ligands (Chemistry), Positron emission |
| Abstract: |
Abstract: The aim of this study was to develop a practical route for preparing a fluorine-18 ([18F]) labelled ligand ([18F]1) containing [18F]fluorobenzene ring by employing the reaction of diphenyliodonium salt with [18F]F−. Diphenyliodonium tosylate (2) was synthesized from tributylphenylstannyl compound (6) with [hydroxy(tosyloxy)iodo]benzene (7). Using this method, [18F]DAA1106 ([18F]3a), a positron emission tomography ligand for imaging peripheral-type benzodiazepine receptor, was prepared. [Copyright &y& Elsevier] |
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| Database: |
Engineering Source |
