Bibliographic Details
| Title: |
Endothelial cell death on biomaterials: Theoretical and practical aspects of investigation |
| Authors: |
Kader, Khalid N. kkader@engineering.uiowa.edu, Yoder, Colin M.1 |
| Source: |
Materials Science & Engineering: C. Apr2008, Vol. 28 Issue 3, p387-391. 5p. |
| Subjects: |
Endothelial seeding, Biomedical materials, Tissue engineering, Fluoropolymers |
| Abstract: |
Abstract: The use of endothelial cell seeding has been proposed as a solution to increase the patency of blood-contacting devices. While there has been a great deal of research into both biological and mechanical mechanisms of failure, relatively little work involving the effects which biomaterials have on the function of cells seeded on such devices has been conducted. We hypothesize, based on previously published results, that endothelial cells attached to synthetic biomaterials exhibit increased intracellular levels of superoxide and other reactive oxygen species. Previous reports have linked elevated levels of reactive oxygen species to NF-κB activation and subsequent cell death via anoikis, a form of apoptosis. Because of this, it is critical that an understanding of how biomaterials affect cellular behavior is developed, and that this knowledge is used in the creation of future devices which rely on cell seeding and cellular ingrowth. [Copyright &y& Elsevier] |
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Copyright of Materials Science & Engineering: C is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Engineering Source |
