Bibliographic Details
| Title: |
A porphyrin–ruthenium photosensitizer as a potential photodynamic therapy agent |
| Authors: |
Davia, Kyle1, King, David2, Hong, Yiling2, Swavey, Shawn1 shawn.swavey@notes.udayton.edu |
| Source: |
Inorganic Chemistry Communications. May2008, Vol. 11 Issue 5, p584-586. 3p. |
| Subjects: |
Nucleic acids, Lymphoid tissue, Cancer cells, Endocrine glands |
| Abstract: |
Abstract: The binding constant of a novel ruthenium–porphyrin to calf thymus DNA is reported. In addition, the ruthenium–porphyrin photocleaves circular plasmid DNA in buffered solutions when irradiated with a 50W tungsten-halogen lamp. The ruthenium–porphyrin shows the ability to diffuse into normal and skin cancer cells and over a 6day period in the absence of light shows no toxicity, however, complete cell death is observed when these cells are irradiated for 1h with a 60W tungsten lamp. [Copyright &y& Elsevier] |
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| Database: |
Engineering Source |
