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A porphyrin–ruthenium photosensitizer as a potential photodynamic therapy agent

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Title: A porphyrin–ruthenium photosensitizer as a potential photodynamic therapy agent
Authors: Davia, Kyle1, King, David2, Hong, Yiling2, Swavey, Shawn1 shawn.swavey@notes.udayton.edu
Source: Inorganic Chemistry Communications. May2008, Vol. 11 Issue 5, p584-586. 3p.
Subjects: Nucleic acids, Lymphoid tissue, Cancer cells, Endocrine glands
Abstract: Abstract: The binding constant of a novel ruthenium–porphyrin to calf thymus DNA is reported. In addition, the ruthenium–porphyrin photocleaves circular plasmid DNA in buffered solutions when irradiated with a 50W tungsten-halogen lamp. The ruthenium–porphyrin shows the ability to diffuse into normal and skin cancer cells and over a 6day period in the absence of light shows no toxicity, however, complete cell death is observed when these cells are irradiated for 1h with a 60W tungsten lamp. [Copyright &y& Elsevier]
Copyright of Inorganic Chemistry Communications is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 31925255
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: A porphyrin–ruthenium photosensitizer as a potential photodynamic therapy agent
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  Data: <searchLink fieldCode="AR" term="%22Davia%2C+Kyle%22">Davia, Kyle</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22King%2C+David%22">King, David</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Hong%2C+Yiling%22">Hong, Yiling</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Swavey%2C+Shawn%22">Swavey, Shawn</searchLink><relatesTo>1</relatesTo><i> shawn.swavey@notes.udayton.edu</i>
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  Data: <searchLink fieldCode="JN" term="%22Inorganic+Chemistry+Communications%22">Inorganic Chemistry Communications</searchLink>. May2008, Vol. 11 Issue 5, p584-586. 3p.
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  Data: <searchLink fieldCode="DE" term="%22Nucleic+acids%22">Nucleic acids</searchLink><br /><searchLink fieldCode="DE" term="%22Lymphoid+tissue%22">Lymphoid tissue</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+cells%22">Cancer cells</searchLink><br /><searchLink fieldCode="DE" term="%22Endocrine+glands%22">Endocrine glands</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Abstract: The binding constant of a novel ruthenium–porphyrin to calf thymus DNA is reported. In addition, the ruthenium–porphyrin photocleaves circular plasmid DNA in buffered solutions when irradiated with a 50W tungsten-halogen lamp. The ruthenium–porphyrin shows the ability to diffuse into normal and skin cancer cells and over a 6day period in the absence of light shows no toxicity, however, complete cell death is observed when these cells are irradiated for 1h with a 60W tungsten lamp. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Inorganic Chemistry Communications is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.inoche.2008.02.023
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      – Code: eng
        Text: English
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        PageCount: 3
        StartPage: 584
    Subjects:
      – SubjectFull: Nucleic acids
        Type: general
      – SubjectFull: Lymphoid tissue
        Type: general
      – SubjectFull: Cancer cells
        Type: general
      – SubjectFull: Endocrine glands
        Type: general
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      – TitleFull: A porphyrin–ruthenium photosensitizer as a potential photodynamic therapy agent
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            NameFull: Davia, Kyle
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            NameFull: King, David
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            NameFull: Hong, Yiling
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            NameFull: Swavey, Shawn
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            – D: 01
              M: 05
              Text: May2008
              Type: published
              Y: 2008
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              Value: 11
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              Value: 5
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            – TitleFull: Inorganic Chemistry Communications
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