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Effect of Molecular Weight and End Capping on Poly(lactic-co-glycolic acid) Ultrasound Contrast Agents.

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Bibliographic Details
Title: Effect of Molecular Weight and End Capping on Poly(lactic-co-glycolic acid) Ultrasound Contrast Agents.
Authors: Eisenbrey, J. R.1 jeisenbrey@gmail.com, Burstein, O. Mualem1, Wheatley, M. A.1
Source: Polymer Engineering & Science. Sep2008, Vol. 48 Issue 9, p1785-1792. 8p.
Subjects: Contrast-enhanced ultrasound, Ultrasound contrast media, Molecular weights, Polymer research, Medical imaging systems, Diagnostic imaging, Emulsion polymerization, Equipment & supplies
Abstract: The article discusses contrast agents (CA) used in the ultrasound medical imaging modality, examining the effects of end capping and molecular weight on hollow CA's which are formed in the double emulsion process. A CA with 50:50 poly (lactic-co-glycolic-acid) (PLGA) is used in a double emulsion process, the authors state. Other topics include non-end capped PLGA which provides a maximum molecular weight enhancement of 18.5 dB and CA's tailored to particular applications by varying the choice of polymer.
Database: Engineering Source
Description
Abstract:The article discusses contrast agents (CA) used in the ultrasound medical imaging modality, examining the effects of end capping and molecular weight on hollow CA's which are formed in the double emulsion process. A CA with 50:50 poly (lactic-co-glycolic-acid) (PLGA) is used in a double emulsion process, the authors state. Other topics include non-end capped PLGA which provides a maximum molecular weight enhancement of 18.5 dB and CA's tailored to particular applications by varying the choice of polymer.
ISSN:00323888
DOI:10.1002/pen.21146