Bibliographic Details
| Title: |
Efficient and reproducible synthesis of [1-11C]acetyl chloride using the loop method |
| Authors: |
Arai, Takuya1, Zhang, Ming-Rong1 zhang@nirs.go.jp, Ogawa, Masanao1,2, Fukumura, Toshimitsu1, Kato, Koichi1, Suzuki, Kazutoshi1 |
| Source: |
Applied Radiation & Isotopes. Feb2009, Vol. 67 Issue 2, p296-300. 5p. |
| Subjects: |
Organic synthesis, Chlorides, Chemical reactions, Grignard reagents, Molecular probes, Polyethylene |
| Abstract: |
Abstract: [1-11C]Acetyl chloride ([11C]AcCl), an important [11C]acylating agent, was synthesized by reacting [11C]CO2 with methylmagnesium bromide coated on the inner surface of a polyethylene loop (loop method). By optimizing the reaction conditions and synthesis parameters, [1-11C]phenylacetate and [1-11C]benzylacetate were produced from [11C]AcCl in high radiochemical yield and specific activity. [Copyright &y& Elsevier] |
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| Database: |
Engineering Source |
