Efficient and reproducible synthesis of [1-11C]acetyl chloride using the loop method
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| Title: | Efficient and reproducible synthesis of [1-11C]acetyl chloride using the loop method |
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| Authors: | Arai, Takuya1, Zhang, Ming-Rong1 zhang@nirs.go.jp, Ogawa, Masanao1,2, Fukumura, Toshimitsu1, Kato, Koichi1, Suzuki, Kazutoshi1 |
| Source: | Applied Radiation & Isotopes. Feb2009, Vol. 67 Issue 2, p296-300. 5p. |
| Subjects: | Organic synthesis, Chlorides, Chemical reactions, Grignard reagents, Molecular probes, Polyethylene |
| Abstract: | Abstract: [1-11C]Acetyl chloride ([11C]AcCl), an important [11C]acylating agent, was synthesized by reacting [11C]CO2 with methylmagnesium bromide coated on the inner surface of a polyethylene loop (loop method). By optimizing the reaction conditions and synthesis parameters, [1-11C]phenylacetate and [1-11C]benzylacetate were produced from [11C]AcCl in high radiochemical yield and specific activity. [Copyright &y& Elsevier] |
| Copyright of Applied Radiation & Isotopes is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 35937541 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Efficient and reproducible synthesis of [1-<superscript>11</superscript>C]acetyl chloride using the loop method – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Arai%2C+Takuya%22">Arai, Takuya</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Ming-Rong%22">Zhang, Ming-Rong</searchLink><relatesTo>1</relatesTo><i> zhang@nirs.go.jp</i><br /><searchLink fieldCode="AR" term="%22Ogawa%2C+Masanao%22">Ogawa, Masanao</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Fukumura%2C+Toshimitsu%22">Fukumura, Toshimitsu</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kato%2C+Koichi%22">Kato, Koichi</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Suzuki%2C+Kazutoshi%22">Suzuki, Kazutoshi</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Applied+Radiation+%26+Isotopes%22">Applied Radiation & Isotopes</searchLink>. Feb2009, Vol. 67 Issue 2, p296-300. 5p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Organic+synthesis%22">Organic synthesis</searchLink><br /><searchLink fieldCode="DE" term="%22Chlorides%22">Chlorides</searchLink><br /><searchLink fieldCode="DE" term="%22Chemical+reactions%22">Chemical reactions</searchLink><br /><searchLink fieldCode="DE" term="%22Grignard+reagents%22">Grignard reagents</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+probes%22">Molecular probes</searchLink><br /><searchLink fieldCode="DE" term="%22Polyethylene%22">Polyethylene</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract: [1-11C]Acetyl chloride ([11C]AcCl), an important [11C]acylating agent, was synthesized by reacting [11C]CO2 with methylmagnesium bromide coated on the inner surface of a polyethylene loop (loop method). By optimizing the reaction conditions and synthesis parameters, [1-11C]phenylacetate and [1-11C]benzylacetate were produced from [11C]AcCl in high radiochemical yield and specific activity. [Copyright &y& Elsevier] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Applied Radiation & Isotopes is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.apradiso.2008.09.013 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 296 Subjects: – SubjectFull: Organic synthesis Type: general – SubjectFull: Chlorides Type: general – SubjectFull: Chemical reactions Type: general – SubjectFull: Grignard reagents Type: general – SubjectFull: Molecular probes Type: general – SubjectFull: Polyethylene Type: general Titles: – TitleFull: Efficient and reproducible synthesis of [1-11C]acetyl chloride using the loop method Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Arai, Takuya – PersonEntity: Name: NameFull: Zhang, Ming-Rong – PersonEntity: Name: NameFull: Ogawa, Masanao – PersonEntity: Name: NameFull: Fukumura, Toshimitsu – PersonEntity: Name: NameFull: Kato, Koichi – PersonEntity: Name: NameFull: Suzuki, Kazutoshi IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2009 Type: published Y: 2009 Identifiers: – Type: issn-print Value: 09698043 Numbering: – Type: volume Value: 67 – Type: issue Value: 2 Titles: – TitleFull: Applied Radiation & Isotopes Type: main |
| ResultId | 1 |
