Bibliographic Details
| Title: |
Incorporation of biotinylated manganese-salen complexes into streptavidin: New artificial metalloenzymes for enantioselective sulfoxidation |
| Authors: |
Pordea, A.1, Mathis, D.1, Ward, T.R.1,2 thomas.ward@unibas.ch |
| Source: |
Journal of Organometallic Chemistry. Mar2009, Vol. 694 Issue 6, p930-936. 7p. |
| Subjects: |
Metal complexes, Streptavidin, Metalloenzymes, Enantioselective catalysis, Oxidation, Ligands (Chemistry), Schiff bases |
| Abstract: |
Abstract: Incorporation of achiral biotinylated manganese-salen complexes into streptavidin yields artificial metalloenzymes for aqueous sulfoxidation using hydrogen peroxide. Four biotinylated salen ligands were synthesized and their manganese complexes were tested in combination with several streptavidin mutants, yielding moderate conversions (up to 56%) and low enantioselectivities (maximum of 13% ee) for the sulfoxidation of thioanisole. [Copyright &y& Elsevier] |
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| Database: |
Engineering Source |
