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Cellular Lipid Metabolism Is Influenced by the Coordination Environment of Copper.

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Bibliographic Details
Title: Cellular Lipid Metabolism Is Influenced by the Coordination Environment of Copper.
Authors: Kennedy, David C.1, Lyn, Rodney K.1, Pezacki, John Paul1 John.Pezacki@nrc-cnrc.gc.ca
Source: Journal of the American Chemical Society. 2/25/2009, Vol. 131 Issue 7, p2444-2445. 2p. 1 Color Photograph, 1 Graph.
Subjects: Lipid metabolism, Copper, Liver cells, Raman effect, Microscopy, Cell metabolism
Abstract: The article presents a study which investigates the effect of the copper (Cu) species on lipid metabolism in liver cells. To observe the size and distribution of lipid bodies in liver cells, coherent anti-Strokes Raman scattering (CARS) microscopy is utilized. Findings suggest that only an excess of complexed Cu result in significant increase in lipid content in liver cells. It was also discovered that Cu overload results in rapid and dramatic increase in lipid body formation.
Database: Engineering Source
Description
Abstract:The article presents a study which investigates the effect of the copper (Cu) species on lipid metabolism in liver cells. To observe the size and distribution of lipid bodies in liver cells, coherent anti-Strokes Raman scattering (CARS) microscopy is utilized. Findings suggest that only an excess of complexed Cu result in significant increase in lipid content in liver cells. It was also discovered that Cu overload results in rapid and dramatic increase in lipid body formation.
ISSN:00027863
DOI:10.1021/ja809451w