Bibliographic Details
| Title: |
Stereoselective synthesis of β-arabino glycosyl sulfones as potential inhibitors of mycobacterial cell wall biosynthesis |
| Authors: |
Ayers, Benjamin1, Long, Hilary2, Sim, Edith2, Smellie, Iain A.1, Wilkinson, Brendan L.1, Fairbanks, Antony J.3 antony.fairbanks@chem.ox.ac.uk |
| Source: |
Carbohydrate Research. Apr2009, Vol. 344 Issue 6, p739-746. 8p. |
| Subjects: |
Inhibitors of bacterial cell wall synthesis, Sulfones, Monosaccharides, Mycobacterium bovis, BCG vaccines, Glycosylation |
| Abstract: |
Abstract: A series of β-arabino glycosyl sulfones with varying alkyl chain lengths were synthesised in a stereoselective fashion as putative mimics of decaprenolphosphoarabinose (DPA), and as potential inhibitors of mycobacterial cell wall biosynthesis. Biological testing against Mycobacterium bovis BCG revealed low to moderate anti-mycobacterial activity with marked dependence on alkyl chain length, which was maximal for a C-12 chain. [Copyright &y& Elsevier] |
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| Database: |
Engineering Source |
