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The Multiple Layers of Ubiquitin-Dependent Cell Cycle Control.

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Bibliographic Details
Title: The Multiple Layers of Ubiquitin-Dependent Cell Cycle Control.
Authors: Wickliffe, Katherine1, Williamson, Adam1, Lingyan Jin1, Rape, Michael1 mrape@berkeley.edu
Source: Chemical Reviews. Apr2009, Vol. 109 Issue 4, p1537-1548. 12p. 4 Black and White Photographs.
Subjects: Ubiquitin, Cancer cell proliferation, Cell proliferation, Cell cycle regulation, Protein research
Abstract: The article focuses on the key concepts which demonstrates how ubiquitination regulates cell cycle progression. It also discusses the impact of of misregulation to aberrant proliferation. It notes that ubiquitination plays an important role on the progression of cell cycle in all eukaryotes. Moreover, multiple layers of regulation from ubiquitin has great potential for future innovative approaches to combat cancer cells proliferation in a more specific and effective ways.
Database: Engineering Source
Description
Abstract:The article focuses on the key concepts which demonstrates how ubiquitination regulates cell cycle progression. It also discusses the impact of of misregulation to aberrant proliferation. It notes that ubiquitination plays an important role on the progression of cell cycle in all eukaryotes. Moreover, multiple layers of regulation from ubiquitin has great potential for future innovative approaches to combat cancer cells proliferation in a more specific and effective ways.
ISSN:00092665
DOI:10.1021/cr800414e