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Cell irradiation setup and dosimetry for radiobiological studies at ELBE

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Title: Cell irradiation setup and dosimetry for radiobiological studies at ELBE
Authors: Zeil, K.1 k.zeil@fzd.de, Beyreuther, E.1, Lessmann, E.1, Wagner, W.1, Pawelke, J.1,2
Source: Nuclear Instruments & Methods in Physics Research Section B. Jul2009, Vol. 267 Issue 14, p2403-2410. 8p.
Subjects: Effect of radiation on cell membranes, Radiation dosimetry, Radiobiology, Electron accelerators, Radiation sources, Photon emission, Channeling (Physics), Bremsstrahlung
Abstract: Abstract: The radiation source ELBE delivers different types of secondary radiation, which is used for cell irradiation studies in radiobiological research. Thereby an important issue is the determination of the biological effectiveness of photon radiation as a function of photon energy by using low-energetic, monochromatic channeling radiation (10–100keV) and high-energetic bremsstrahlung (up to 40MV). Radiobiological studies at the research facility ELBE demand special technical and dosimetric prerequisites. Therefore, a cell irradiation system (CIS) has been designed, constructed and installed at the beam line. The CIS allows automatic irradiation of a larger cell sample number and the compensation of spatial inhomogeneity of the dose distribution within the beam spot. The recently introduced GafChromic® EBT radiochromic film model has been used to verify the cell irradiation dose deposition achieving a dose uncertainty of <5%. Both, the installed cell irradiation system and the developed dosimetric procedure based on the use of the EBT film have been experimentally tested at ELBE. The biological effectiveness of 34MV bremsstrahlung with respect to 200kV X-rays from a conventional X-ray tube has been determined. An RBE value of 0.75 has been measured in good agreement with literature. [Copyright &y& Elsevier]
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Database: Engineering Source
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Abstract:Abstract: The radiation source ELBE delivers different types of secondary radiation, which is used for cell irradiation studies in radiobiological research. Thereby an important issue is the determination of the biological effectiveness of photon radiation as a function of photon energy by using low-energetic, monochromatic channeling radiation (10–100keV) and high-energetic bremsstrahlung (up to 40MV). Radiobiological studies at the research facility ELBE demand special technical and dosimetric prerequisites. Therefore, a cell irradiation system (CIS) has been designed, constructed and installed at the beam line. The CIS allows automatic irradiation of a larger cell sample number and the compensation of spatial inhomogeneity of the dose distribution within the beam spot. The recently introduced GafChromic® EBT radiochromic film model has been used to verify the cell irradiation dose deposition achieving a dose uncertainty of <5%. Both, the installed cell irradiation system and the developed dosimetric procedure based on the use of the EBT film have been experimentally tested at ELBE. The biological effectiveness of 34MV bremsstrahlung with respect to 200kV X-rays from a conventional X-ray tube has been determined. An RBE value of 0.75 has been measured in good agreement with literature. [Copyright &y& Elsevier]
ISSN:0168583X
DOI:10.1016/j.nimb.2009.04.015