Bibliographic Details
| Title: |
HDAC2 Promotes elF4E Sumoylation and Activates mRNA Translation Gene Specifically. |
| Authors: |
Xiang Xu1,2, Vatsyayan, Jaya1, Chenxi Gao1, Bakkenist, Christopher J.1,3, Jing Hu1 huj3@upmc.edu |
| Source: |
Journal of Biological Chemistry. 6/11/2010, Vol. 285 Issue 24, p18139-18143. 5p. 2 Diagrams, 2 Graphs. |
| Subjects: |
Histone deacetylases, Genetic transcription, Messenger RNA, Cell proliferation, Apoptosis, Protein synthesis |
| Abstract: |
Histone deacetylases (HDACs) are best known as transcription corepressors through deacetylating histone tails. Here we show that HDAC2 is also involved in cap-dependent mRNA translation by promoting sumoylation of eukaryotic translation initiation factor 4E (eIF4E), which is independent of its deacetylase activity. By stimulating eIF4E sumoylation, HDAC2 induces the formation of the active eukaryotic initiation factor 4F (eIF4F) complex and induces the protein synthesis of a subset of elF4E-responsive genes that are essential for cell proliferation and preventing apoptosis. These data demonstrate that HDAC2 has an unexpected sumoylation-promoting activity and regulates cap-dependent mRNA translation. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
